Results 121 to 130 of about 819,058 (310)

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Effects of Lee Silverman Voice Treatment^® BIG on At-Home Physical Activity in Individuals with Parkinson’s Disease: A Preliminary Retrospective Observational Study

Applied Sciences
In individuals with Parkinson’s disease (PD), bradykinesia severity is related to physical activity (PA) inside homes. We aimed to investigate the effectiveness of the Lee Silverman Voice Treatment (LSVT)® BIG intervention in increasing at-home PA in ...
Yuichi Hirakawa, Hiroaki Sakurai, Soichiro Koyama, Kazuya Takeda, Masanobu Iwai, Ikuo Motoya, Yoshikiyo Kanada, Nobutoshi Kawamura, Mami Kawamura, Shigeo Tanabe   +9 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Dietary habits and adherence to the Mediterranean diet in a cohort of Parkinson’s disease patients in Lithuania

Frontiers in Nutrition
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. A growing body of evidence shows that a healthy diet, including the Mediterranean diet (MeDi), can slow the disease progression and improve ...
Jevgenija Guk, Rūta Kaladytė Lokominienė, Anatolij Nečiporenko, Dalius Jatužis   +3 more
doaj   +1 more source

Self-Perceived Pre-Motor Symptoms Load in Patients with Parkinson’s Disease: A Retrospective Study

Journal of Parkinson’s Disease, 2016
Background: Parkinson’s disease is characterized by motor and non-motor clinical features. The latter may present as pre-motor symptoms several years before the motor onset.
Mayela Rodríguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Roxanna Millán-Cepeda, Roberto Leal-Ortega, Ingrid Estrada-Bellmann, Carlos Zuñiga-Ramírez   +6 more
doaj   +1 more source

Non-motor symptoms in dystonia

, 2022
Dystonia is a movement disorder in which patients suffer from involuntary repetitive movements and/or abnormal postures. In addition to the problems with movement, patients also have non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue. These non-motor symptoms often remain underexposed, but they do have a great influence on the
openaire   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Management of migraine [PDF]

, 1999
Migraine is a complex neurovascular disease characterised by episodic attacks of severe headache accompanied by autonomic and neurological symptoms. Two types of migraine have been identified: (1) common migraine, or migraine without aura, occurring in ...
Farrugia, Isabelle
core  

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source