Results 61 to 70 of about 818,047 (308)

Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: a systematic review and meta-analysis [PDF]

, 2017
Introduction: Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed ...
Hegarty, Shane V., Lee, David J., O'Keeffe, Gerard W., Sullivan, Aideen M.   +3 more
core   +1 more source

Pathophysiological process underlying Parkinson's disease: Motor & Non-motor symptoms

Rinsho Shinkeigaku, 2009
It is proposed that alpha-synucleinopathy initially affects the medulla oblongata and then progresses to more rostral brain areas ("Braak hypothesis"). According to this hypothesis, substantia nigra is affected in the later stages of PD. Another region affected in the earlier stages was reported to be olfactory bulb, although the following processes ...
Atsushi, Takeda, Toru, Baba, Akio, Kikuchi, Naoto, Sugeno, Takafumi, Hasegawa, Yasuto, Itoyama, Toshiyuki, Ishioka, Kazumi, Hirayama, Etsuro, Mori   +8 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The psychological impact of motor vehicle accidents : a New Zealand study : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Psychology at Massey University [PDF]

, 1997
PLEASE NOTE Pages 72-73 are missing from the original copyThe present research attempted to identify those factors which predispose victims of severe motor vehicle accidents to develop PTSD, and explored the relationship between mental health and health ...
Kennedy-Moffat, James
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms

Frontiers in Neurology, 2020
Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes.
Michelle E. Fullard, John E. Duda, John E. Duda   +2 more
doaj   +1 more source

Non-motor symptoms in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2023
While motor symptoms are well-known in ALS, non-motor symptoms are often under-reported and may have a significant impact on quality of life. In this study, we aimed to examine the nature and extent of non-motor symptoms in ALS.A 20-item questionnaire was developed covering the domains of autonomic function, sleep, pain, gastrointestinal disturbance ...
Ali Shojaie, Ahmad Al Khleifat, Sarah Opie-Martin, Payam Sarraf, Ammar Al-Chalabi   +4 more
openaire   +4 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

An Empirical Examination of Symptom Substitution Associated with Behavior Therapy for Tourette\u27s Disorder [PDF]

, 2016
Over the past six decades, behavior therapy has been a major contributor to the development of evidence-based psychotherapy treatments. However, a long-standing concern with behavior therapy among many nonbehavioral clinicians has been the potential risk
Hatch, John P., McGuire, Joseph F., Peterson, Alan L., Piacentini, John, Scahill, Lawrence, Villarreal, Robert, Walkup, John T., Wilhelm, Sabine, Woods, Douglas W.   +8 more
core   +1 more source

Automated operant assessments of Huntington's Disease mouse models [PDF]

, 2018
Huntington’s disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to ...
A Burns, A Lunkes, AD Lawrence, AD Lawrence, AE Horner, AJ Mitchell, AJ Morton, B Baldo, B Skinner, C Clelland, C Kipps, CF Jacobsen, CL Julien, D Craufurd, D Helder, D Yang, DC Rogers, E Dowd, E Dowd, E Mayer, E Yhnell, E Yhnell, E Yhnell, F Yue, J Paulsen, J Snowden, J Talpos, J-C Bensadoun, JC Jacobsen, JC Thompson, JF Gusella, JM Raamsdonk Van, JN Crawley, JR Slaughter, JS Paulsen, K Kubota, L Mangiarini, L Menalled, M Carli, M Carli, M D’amato, MD Döbrössy, MD Döbrössy, ME MacDonald, P Thompson, PC Curtin, PJ Brasted, PW Faber, R Diamond, RC Josiassen, RC Trueman, RC Trueman, RC Trueman, RC Trueman, RC Trueman, RE Ready, S Baudic, S Brooks, S Brooks, S Hörsten von, S Kirkwood, S Klöppel, S-H Yang, SA Johnson, SB Dunnett, SB Dunnett, SB Dunnett, SB Dunnett, SB Dunnett, SJ Tabrizi, SJ Tabrizi, SJ Tabrizi, SM McTighe, SP Brooks, SP Brooks, SP Brooks, T Humby, T Robbins, T-B Robins Wahlin, V Tucci, W Duan, WD Spaulding   +81 more
core   +2 more sources