Results 51 to 60 of about 4,395,352 (325)
Mouse models and mouse supermodels
EMBO Molecular Medicine, 2010 Varnat et al, EMBO Mol Med, 1, 338–351, report that Hedgehog (HH) signalling is essential for growth of human colon carcinoma (CC) (Varnat et al, 2009). In the accompanying Closeup article (Gulino et al, 2009) state that while participation of the HH pathway in CC has been controversial because of conflicting and contradictory data (Varnat et al, 2009)
openaire +2 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The orienting mouse: An input device with attitude [PDF]
, 2013 This paper presents a modified computer mouse, the Orienting Mouse, which delivers orientation as an additional dimension of input; when the mouse is moved on a flat surface it reports, in addition to the conventional x, y translation, angular rotation ...
Apperley, Mark, Rogers, Bill
core +1 more source
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]
, 2018 CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino +13 more
core +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
”PENGARUH BERBAGAI DOSIS FILTRAT DAUN COCOR BEBEK \ud (Kalanchoe pinnata L.) TERHADAP PENURUNAN SUHU TUBUH TIKUS \ud PUTIH (Rattus norvegicus) HIPERTERMIA” [PDF]
, 2009 Fever is situation of body temperature above normal as effect of make-up of center arrangement of temperature in hipotalamus which in influencing by IL-I.
WIJAYANTI, YUNI
core
Intrusion Detection Using Mouse Dynamics
, 2018 Compared to other behavioural biometrics, mouse dynamics is a less explored area. General purpose data sets containing unrestricted mouse usage data are usually not available.
Antal, Margit, Egyed-Zsigmond, Elod
core +2 more sources
Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]
, 2003 The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J. +3 more
core +1 more source