Results 131 to 140 of about 60,701 (176)

Sandwich enzyme immunoassay of mouse mammary tumor virus

Experientia, 1981
A highly sensitive sandwich enzyme immunoassay for the mouse mammary tumor virus (MMTV) is described. The assay can detect 3 ng/ml of MMTV. The enzyme used is s-D-galactosidase fromEscherichia coli and the solid phase used is a piece of silicon rubber.
M, Takahashi, S, Saga, S, Nagayoshi, M, Imai, Y, Tsutsui, K, Kato, M, Hoshino   +6 more
openaire   +2 more sources

Quantification of mouse mammary tumor virus structural proteins in hormone‐induced mammary tumors of low mammary tumor mouse strains

International Journal of Cancer, 1980
AbstractThe expression of the mouse mammary tumor virus (MMTV) in hormone‐induced mammary tumors was investigated by means of a radioimmunoassay for two major MMTV proteins, gp52 and p27. MMTV proteins were isolated on lectin affinity‐ and ion‐exchange chromatography columns. The purified viral proteins were electrophoretically homogeneous and retained
Nusse, R, Michalides, R, Boot, L M, Ropcke, G   +3 more
openaire   +2 more sources

Mouse mammary tumor virus and mammary tumorigenesis in wild mice

Pathology International, 1996
The current knowledge of the distribution of the mouse mammary tumor virus (MMTV) proviral genomes and the mechanism of mammary tumorigenesis by MMTV in mice, with the main emphasis on Asian feral mice, is reviewed. The relevant earlier discoveries on the mode of MMTV transmission are summarized to provide an outline of the biology of MMTV.
openaire   +2 more sources

Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains

Journal of Virology, 1978
The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained.
Michalides, R, Deemter, L V, Nusse, R, Ropcke, G, Boot, L   +4 more
openaire   +2 more sources

Mouse Mammary Tumor Virus and the Immune System

Immunologic Research, 2003
Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells.
Jennifer, Czarneski, John C, Rassa, Susan R, Ross   +2 more
openaire   +2 more sources

Immune response to mouse mammary tumor virus

Current Opinion in Immunology, 1996
Superantigens of mouse mammary tumor virus induce a strong cognate interaction between T cells and B cells. In addition to amplifying the virus-infected B-cell pool, this superantigen-driven interaction leads to the differentiation of virus-specific B cells into plasma cells. Successful interaction between T cells and B cells is required for completion
S A, Luther, H, Acha-Orbea
openaire   +2 more sources

Selective amplification of mouse mammary tumor virus in mammary tumors of GR mice

Journal of Virology, 1980
DNAs extracted from the mammary tumors of GR mice were analyzed for mouse mammary tumor virus proviral sequences by the restriction enzyme-Southern blot procedure. The tumor DNAs contain more proviral copies of mouse mammary tumor virus than DNA from a nonmalignant tissue. The degree of proviral amplification is small (ca. one to five additional copies)
T G, Fanning, J P, Puma, R D, Cardiff
openaire   +2 more sources

Molecular Aspects of Mouse Mammary Tumor Virus Biology

1987
Publisher Summary This chapter outlines the structure and replication of the mouse mammary tumor virus (MMTV), and elaborates those aspects of MMTV molecular biology that have provided an insight into the understanding of gene regulation and virally induced carcinogenesis.
openaire   +2 more sources

Mouse Mammary Tumor Virus and Cancer

2011
The retrovirus mouse mammary tumor virus (MMTV) was discovered in the 1930s as a milk-transmitted agent that causes breast cancer in mice. MMTV causes mammary tumors by insertional activation or mutation of cellular oncogenes. Some of the oncogenes activated by MMTV insertion have been also associated with human breast cancer.
openaire   +1 more source

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly