Results 11 to 20 of about 2,749,540 (299)
Mouse models of medulloblastoma [PDF]
Chinese Journal of Cancer, 2011 Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of ...
Wu, Xiaochong +3 more
openaire +2 more sources
International Journal of Molecular Sciences, 2021 Chronic myelomonocytic leukemia (CMML) is a rare and challenging type of myeloproliferative neoplasm. Poor prognosis and high mortality, associated predominantly with progression to secondary acute myeloid leukemia (sAML), is still an unsolved problem.
Ekaterina Belotserkovskaya, Oleg Demidov
openaire +2 more sources
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. [PDF]
, 2016 Patient-derived xenograft (PDX) mouse models of cancer are emerging as an important component of personalized precision cancer therapy. However, most models currently offered to patients have their tumors subcutaneously-transplanted in immunodeficient ...
Bouvet, Michael +10 more
core +2 more sources
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome [PDF]
, 2009 Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O’Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033–
Bliss, T.V.P. +7 more
core +3 more sources
Prevalence of sexual dimorphism in mammalian phenotypic traits
Nature Communications, 2017 Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory ...
Natasha A. Karp +43 more
doaj +1 more source
Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders. [PDF]
, 2015 Distinctive features in sensory event-related potentials (ERPs) are endophenotypic biomarkers of psychiatric disorders, widely studied using electroencephalographic (EEG) methods in humans and model animals. Despite the popularity and unique significance
Behrens, M Margarita +4 more
core +2 more sources
Platelets, 2020 Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders ...
Bassem M. Mohammed +2 more
openaire +4 more sources
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD. [PDF]
, 2020 Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood.
Chen, Naiyan +16 more
core +1 more source
Journal of Translational Medicine, 2023 Background Infection with high-risk human papillomavirus (HPV) strains is one of the risk factors for the development of oral squamous cell carcinoma (OSCC).
Ziva Modic +6 more
doaj +1 more source