Results 11 to 20 of about 1,587,863 (170)

Generation of an immunodeficient mouse model of tcirg1-deficient autosomal recessive osteopetrosis

Bone Reports, 2020
Background: Autosomal recessive osteopetrosis is a rare skeletal disorder with increased bone density due to a failure in osteoclast bone resorption. In most cases, the defect is cell-autonomous, and >50% of patients bear mutations in the TCIRG1 gene ...
Eleonora Palagano, Sharon Muggeo, Laura Crisafulli, Irina L. Tourkova, Dario Strina, Stefano Mantero, Elena Fontana, Silvia L. Locatelli, Marta Monari, Emanuela Morenghi, Carmelo Carlo-Stella, John B. Barnett, Harry C. Blair, Paolo Vezzoni, Anna Villa, Cristina Sobacchi, Francesca Ficara   +16 more
doaj   +1 more source

Prevalence of sexual dimorphism in mammalian phenotypic traits

Nature Communications, 2017
Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory ...
Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, International Mouse Phenotyping Consortium, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White   +43 more
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Mouse models of hemostasis

Platelets, 2020
Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders ...
Bassem M. Mohammed, Dougald M. Monroe, David Gailani   +2 more
openaire   +4 more sources

HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studies

Journal of Translational Medicine, 2023
Background Infection with high-risk human papillomavirus (HPV) strains is one of the risk factors for the development of oral squamous cell carcinoma (OSCC).
Ziva Modic, Maja Cemazar, Bostjan Markelc, Andrej Cör, Gregor Sersa, Simona Kranjc Brezar, Tanja Jesenko   +6 more
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Autoimmune Pancreatitis Mouse Model [PDF]

Current Protocols in Immunology, 2018
AbstractAutoimmune pancreatitis (AIP) is a chronic fibro‐inflammatory disorder of the pancreas. However, extensive clinico‐pathological analyses have revealed that AIP is, in reality, a pancreatic manifestation of a newly described systemic disease known as IgG4‐related disease (IgG4‐RD).
Ken, Kamata, Tomohiro, Watanabe, Kosuke, Minaga, Warren, Strober, Masatoshi, Kudo   +4 more
openaire   +2 more sources

Conditional Expression of Human 15-Lipoxygenase-1 in Mouse Prostate Induces Prostatic Intraepithelial Neoplasia: The FLiMP Mouse Model

Neoplasia: An International Journal for Oncology Research, 2006
The incidence and mortality of prostate cancer (PCa) vary greatly in different geographic regions, for which lifestyle factors, such as dietary fat intake, have been implicated.
Uddhav P. Kelavkar, Anil V. Parwani, Scott B. Shappell, W. David Martin   +3 more
doaj   +1 more source

Complement Properdin Determines Disease Activity in MRL/lpr Mice

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
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A novel orthotopic mouse model replicates human lung cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle, 2023
Introduction Cancer cachexia, highly prevalent in lung cancer, is a debilitating syndrome characterized by involuntary loss of skeletal muscle mass and is associated with poor clinical outcome, decreased survival and negative impact on tumour therapy ...
Wouter R.P.H. van deWorp, Jan Theys, Alba Sanz González, Brent van derHeyden, Frank Verhaegen, Duncan Hauser, Florian Caiment, Hubertus J.M. Smeets, Annemie M.W.J. Schols, Ardy vanHelvoort, Ramon C.J. Langen   +10 more
doaj   +1 more source

Translational relevance of behavioral, neural, and electroencephalographic profiles in a mouse model of post-traumatic stress disorder

Neurobiology of Stress, 2021
Post-traumatic stress disorder (PTSD) is a severe, long-term psychological disorder triggered by distressing events. The neural basis and underlying mechanisms of PTSD are not completely understood.
Kaiwen Xi, Xin Huang, Tiaotiao Liu, Yang Liu, Honghui Mao, Mengmeng Wang, Dayun Feng, Wenting Wang, Baolin Guo, Shengxi Wu   +9 more
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Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions

Pathogens, 2014
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma.
Tadashi Inuzuka, Ken Takahashi, Tsutomu Chiba, Hiroyuki Marusawa   +3 more
doaj   +1 more source