Results 271 to 280 of about 1,832,552 (317)
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Hospital Practice, 1996
Mice that are lacking their own lymphocytes are given a human immune system, which then is infected with HIV. Such models are proving themselves in studies of immunization techniques. They also yield insights into HIV, including its capacity for infecting particular cell types and its so-called accessory genes.
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Mice that are lacking their own lymphocytes are given a human immune system, which then is infected with HIV. Such models are proving themselves in studies of immunization techniques. They also yield insights into HIV, including its capacity for infecting particular cell types and its so-called accessory genes.
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2019
Yersiniosis is common foodborne gastrointestinal disease caused by the enteric pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis. The mouse model of oral infection serves as a useful tool to study enteropathogenic Yersinia infection in mammals.
Diana, Hooker-Romero +3 more
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Yersiniosis is common foodborne gastrointestinal disease caused by the enteric pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis. The mouse model of oral infection serves as a useful tool to study enteropathogenic Yersinia infection in mammals.
Diana, Hooker-Romero +3 more
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Mouse Model for Pyelonephritis
Current Protocols in Immunology, 2013AbstractThis unit describes a simple way to induce pyelonephritis in female mice using uropathogenic Escherichia coli (UPEC). Methods for culturing and preparing working stocks of UPEC are provided. Protocols to measure the bacterial load in the murine kidney following the establishment of pyelonephritis by determining the bacterial colony forming ...
André P, Tittel +2 more
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Annual Review of Pathology: Mechanisms of Disease, 2011
Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, gaining insight into the molecular and cellular mechanisms underlying tumor initiation and multistage processes of tumorigenesis, and
Dong-Joo, Cheon, Sandra, Orsulic
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Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, gaining insight into the molecular and cellular mechanisms underlying tumor initiation and multistage processes of tumorigenesis, and
Dong-Joo, Cheon, Sandra, Orsulic
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Physiology & Behavior, 1982
A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time.
H, Rijk, J C, Crabbe, H, Rigter
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A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time.
H, Rijk, J C, Crabbe, H, Rigter
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Clinics in Dermatology, 2004
Insights into the etiology of human obesity have arisen from the study of animal models. Animal models of obesity are also important for the development of future treatments of obesity. An agouti mouse mutation resulting in obese, yellow mice was described over a century ago and in 1992 agouti was cloned, making it the first obesity gene characterized ...
Carroll, Levi +2 more
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Insights into the etiology of human obesity have arisen from the study of animal models. Animal models of obesity are also important for the development of future treatments of obesity. An agouti mouse mutation resulting in obese, yellow mice was described over a century ago and in 1992 agouti was cloned, making it the first obesity gene characterized ...
Carroll, Levi +2 more
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2018
Mouse models are critical for delineating the mechanisms that underlie asthma pathogenesis and developing new treatments. In this chapter we describe four different asthma models that offer unique benefits and allow investigators to answer distinct research questions.
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Mouse models are critical for delineating the mechanisms that underlie asthma pathogenesis and developing new treatments. In this chapter we describe four different asthma models that offer unique benefits and allow investigators to answer distinct research questions.
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Mouse models of holoprosencephaly
Current Opinion in Neurology, 2003Holoprosencephaly (HPE) is the most common anomaly of forebrain development in humans. The pathogenesis of HPE results in a failure of the brain hemispheres to separate during early development. Here we review experimental models of HPE in which some of the genes known to cause HPE in humans have been disrupted in the mouse.To date, mutations that ...
Monica, Hayhurst, Susan K, McConnell
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Journal of Investigative Dermatology
Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch ...
Daniel, Yassky, Brian S, Kim
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Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch ...
Daniel, Yassky, Brian S, Kim
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Mouse models in oncoimmunology
Nature Reviews Cancer, 2016Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies - each with their specific advantages and difficulties ...
Zitvogel, Laurence +4 more
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