Results 281 to 290 of about 1,832,552 (317)
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2014
Severe thermal injury induces immunosuppression, involving all parts of the immune system, especially when large fractions of the total body surface area are affected. An animal model was established to characterize the burn-induced immunosuppression. In our novel mouse model a 6 % third-degree burn injury was induced with a hot-air blower.
Henrik, Calum +2 more
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Severe thermal injury induces immunosuppression, involving all parts of the immune system, especially when large fractions of the total body surface area are affected. An animal model was established to characterize the burn-induced immunosuppression. In our novel mouse model a 6 % third-degree burn injury was induced with a hot-air blower.
Henrik, Calum +2 more
openaire +2 more sources
2023
Animal models have been crucial in understanding the pathogenesis and developing novel therapeutic approaches for fungal infections in general. This is especially true for mucormycosis, which has a low incidence but is often fatal or debilitating.
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Animal models have been crucial in understanding the pathogenesis and developing novel therapeutic approaches for fungal infections in general. This is especially true for mucormycosis, which has a low incidence but is often fatal or debilitating.
openaire +2 more sources
Current Protocols in Mouse Biology, 2016
AbstractAllergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen‐specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, and structural changes in the airways.
Nincy, Debeuf +4 more
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AbstractAllergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen‐specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, and structural changes in the airways.
Nincy, Debeuf +4 more
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2018
Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their ...
Karina A, Serban, Irina, Petrache
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Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their ...
Karina A, Serban, Irina, Petrache
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Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2007
The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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Trends in Endocrinology & Metabolism, 2007
The process of implantation, necessary for nearly all viviparous birth, consists of tightly regulated reactions including apposition of the blastocyst, attachment to the uterine epithelium and decidualization of the uterine stroma. In order for implantation to be successful, a reciprocal interaction between an implantation competent blastocyst and ...
Kevin Y, Lee +4 more
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The process of implantation, necessary for nearly all viviparous birth, consists of tightly regulated reactions including apposition of the blastocyst, attachment to the uterine epithelium and decidualization of the uterine stroma. In order for implantation to be successful, a reciprocal interaction between an implantation competent blastocyst and ...
Kevin Y, Lee +4 more
openaire +2 more sources
Thrombosis and Haemostasis, 2002
In the past six years, analysis of numerous murine models, enabled by investigator-designed manipulation of the mouse genome, has gene-rated an explosion of new, and sometimes confounding, data. Mice with complete deficiencies in virtually all the known factors involved in hemostasis have been produced by targeted modification of the genes that encode ...
Kelly A, Hogan +2 more
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In the past six years, analysis of numerous murine models, enabled by investigator-designed manipulation of the mouse genome, has gene-rated an explosion of new, and sometimes confounding, data. Mice with complete deficiencies in virtually all the known factors involved in hemostasis have been produced by targeted modification of the genes that encode ...
Kelly A, Hogan +2 more
openaire +2 more sources
Current Atherosclerosis Reports, 2000
Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystrophy syndrome, offering insights into ...
K, Reue, M, Péterfy
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Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystrophy syndrome, offering insights into ...
K, Reue, M, Péterfy
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Mouse Models of Atherosclerosis
Science, 1996As a species the mouse is highly resistant to atherosclerosis. However, through induced mutations it has been possible to develop lines of mice that are susceptible to this disease. For example, mice that are deficient in apolipoprotein E, a ligand important in lipoprotein clearance, develop atherosclerotic lesions resembling those observed in humans ...
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Journal of Neuro-Oncology, 2010
Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery. In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades. As rodents very rarely develop
Michel, Kalamarides +2 more
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Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery. In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades. As rodents very rarely develop
Michel, Kalamarides +2 more
openaire +2 more sources