Results 101 to 110 of about 4,135 (173)

MPXV Sequencing from Wastewater (Illumina) V1.0 v1

This protocol is designed to sequence MPXV from wastewater samples using a limited amplicon scheme that targets all MPXV clades, subclades, and lineages.
Allison Steedman, Mark Zeller
openaire   +1 more source

In-silico primer designing and PCR for detection of monkeypox virus (MPXV)

Journal of Infection and Public Health, 2022
Ying Wei Khoo, Shifang Li, Khim Phin Chong   +2 more
openaire   +3 more sources

The pathogenicity and multi-organ proteomic profiles of Mpox virus infection in SIVmac239-infected rhesus macaques

Nature Communications
Mpox poses a heightened risk of severe disease and mortality among individuals with HIV, yet the molecular mechanisms and immunopathology underlying multi-organ damage caused by the mpox virus (MPXV), particularly in the context of HIV co-infection ...
Dong Zhang, Jiangfeng Liu, Lin Zhu, Baoying Huang, Zhe Cong, Na Li, Jingjing Zhang, Ting Chen, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Chenbo Yang, Wanjun Peng, Qiang Wei, Wenjie Tan, Juntao Yang, Jing Xue   +16 more
doaj   +1 more source

MPXV replication and drug resistance in CNS of advanced HIV case at autopsy

Abstract Monkeypox virus (MPXV) clade IIb caused an outbreak of >100,000 cases globally, with highest disease burden in people living with advanced human immunodeficiency virus (HIV), those with CD4 count <200 cells/mm3. We performed an extensive autopsy on a fatal case of mpox in a person living with advanced HIV-1, who achieved ...
Daniel Chertow, Maria Charles, Sofia Romero Ferrufino, Sabrina Ramelli, Shane Gallogly, Claude Kwe Yinda, Divya Ahuja, Edwin Hayes, Morgan Pizzuti, Kevin Vannella, Craig Martens, Franziska Kaiser, Andrew Platt, Martha Quezado, Christopher Morris, Vincent Munster, Stephen Hewitt   +16 more
openaire   +3 more sources

Development of a replication-defective MPXV platform for fundamental and therapeutic research

ABSTRACT The recent global outbreaks of mpox highlight the urgent need for both fundamental research and antiviral development. However, studying monkeypox virus (MPXV), with its large and complex genome, remains challenging due to the requirement for high-containment facilities. Here, we describe a novel strategy for
Jiannan Chen, Liyuan Hu, Ning Shi, Jiaxin Tian, Yuyi Zhang, Sicheng Tian, Xinyu Cao, Zhuo Ha, Qiliang Cai, Yongxu Lu, Geoffrey L. Smith, Youhua Xie, Huijun Lu, Ping Zhang, Rong Zhang   +14 more
openaire   +1 more source

ISG15 Differentially Modulates Clade Ib and II MPXV Infection

Abstract The unprecedented human-to-human transmission of Clade IIb monkeypox virus (MPXV) during the 2022 outbreak has renewed focus on host determinants of viral fitness. Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein with broad immunomodulatory functions, yet its role in MPXV infection remains unclear.
Susana Guerra, Joseph McGrail, Irene Campaña Gómez, Antti Tuhkala, Salla Keskitalo, Markku Varjosalo, Adolfo Garcia-Sastre, Gustavo Palacios, Mari Sánchez-Seco   +8 more
openaire   +1 more source

Monckeypox virus (MPXV)

, 2022
Vandenbergen, Liselot, Vandercam, Geoffroy, Hoornaert, Ellen, Sluijters, Alice, Yombi, Jean Cyr   +4 more
openaire   +1 more source

Erratum for Li et al., “Bispecific antibodies targeting MPXV A29 and B6 demonstrate efficacy against MPXV infection”

Journal of Virology
Mengjun Li, Jiayin Chen, Fuxiang Wang, Jiahua Kuang, Yun Peng, Sadia Asghar, Wei Zhao, Yang Yang, Chenguang Shen   +8 more
openaire   +2 more sources

Molecular detection of potential alternative pathogens among MPXV-negative suspected mpox cases in Sierra Leone, 2025. [PDF]

New Microbes New Infect
Harding D, Ndiaye M, Faye M, Gaye A, Top FK, Barry MA, Campbell AKO, Kane M, Chalobah F, Fofanah A, Ruhweza S, Diouf AM, Koninga K, Diagne MM, Cissé M, Koroma A, Faye O, Dia N, Loucoubar C, Sow DY, Squire J, Jalloh MB, Diarrassouba M, Diallo B, Vandi MA, Sow A, Sombié I, Sahr F, Wurie I, Sall AA, Grant DS, Fall IS, Norman JA.   +32 more
europepmc   +1 more source

Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes. [PDF]

Cell Rep Med
Chen L, Zhang G, Lin H, Zhang Y, Li J, Shu L, Wang X, Li R, Zhao F, Zhao X, Yang Y, Zhang Z, Zhang J, Wei C, Chi X, Zai X, Xu J.   +16 more
europepmc   +1 more source