Results 151 to 160 of about 4,135 (173)

MPXV data

README This is the relevant data of paper titled 'A population-based study of monkeypox virus genetic evolution and clinical association in its recent epidemics in Shenzhen'. All the human participants are anonymized. The 'mpox_severity_shenzhen_anonymized' dataset contains sequence quality control scores and clinical severity scores for enrolled ...
Lv, Ziquan, Wang, Haitian, Hu, Qinghua, Kong, Dongfeng   +3 more
openaire   +3 more sources

Pathogenicity and Contact Transmissibility of Clade IIb MPXV in African Dormice

Emerging Microbes and Infections
The global outbreak of monkeypox virus (MPXV) in 2022 raised widespread scientific concern regarding potential changes in its biological characteristics. In this study, we conducted research on the pathogenicity and transmissibility of the currently circulating MPXV Clade IIb strain.
Wang Zhenjun, Changbo Ou, Zongzheng Zhao
exaly   +3 more sources

Monkeypox Virus (MPXV) Infection: A Review

Infectious Disorders - Drug Targets
Abstract: Monkeypox is a viral disease; its outbreak was recently declared a global emergency by the World Health Organization. For the first time, a monkeypox virus (MPXV)-infected patient was found in India. Various researchers back-to-back tried to find the solution to this health emergency just after COVID-19.
Rosy, Kumari, Pooja, Arya, Surya Prakash, Yadav, Ratish Chandra, Mishra, Jaya Parkash, Yadav   +4 more
openaire   +2 more sources

Examining Homology Between MPXV and Immunogenic VACV-Derived Peptides

Vaccine
The mpox virus (MPXV) came to global attention with the 2022 global outbreak. Current vaccination and post-exposure prophylaxis against MPXV consists of live vaccinia whole virus-based vaccines including ACAM2000®, JYNNEOS™, and LC16m8 originally developed against smallpox.
Gregory A. Poland, Richard B Kennedy, Inna G Ovsyannikova   +2 more
exaly   +3 more sources

Inefficient Tissue Immune Response Against MPXV in an Immunocompromised Mpox Patient

Journal of Medical Virology
AbstractThe recent outbreak of monkeypox virus (MPXV) was unprecedented in its size and distribution. Those living with uncontrolled HIV and low CD4 T cell counts might develop a fulminant clinical mpox course with increased mortality, secondary infections, and necrotizing lesions. Fatal cases display a high and widespread MPXV tissue burden.
Susanne Krasemann, Kristin Hartmann
exaly   +3 more sources

Bioinformatics, expression, and immunogenicity analysis of MPXV A7 protein

Protein Expression and Purification
Since the World Health Organization designated the Monkeypox (mpox) outbreak a Public Health Emergency of International Concern (PHEIC) in 2022, monkeypox virus (MPXV) has spread across all six continents. However, the virus's genomic variability and strong adaptability have thus far hindered the development of effective, targeted vaccines.
Chenyi, Wang, Jiaqi, Xiong, Hao, Zhou, Haorui, Zhu, Zixuan, Li, Jiaxin, Li, Mingzhi, Li, Qi, Peng, Ting, Wang, Lingbao, Kong   +9 more
openaire   +2 more sources

Tracing the footprints of MPXV in Asia: phylogenetic insights and lineage dynamics

Sexually Transmitted Infections
ObjectivesThe 2022 global outbreak of monkeypox virus (MPXV), previously confined to Central and West Africa, necessitates an enhanced understanding of its spread. Comprehensive genomic surveillance to understand the virus’s evolution and spread is needed, particularly in Asia.MethodsGenomic data from 169 MPXV genome sequences in Asia were analysed ...
Yung-Chun Chen, Yu-Chieh Liao, Yan-Chiao Mao, Ting-Kuang Yeh, Po-Yu Liu   +4 more
openaire   +2 more sources

Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo

New England Journal of Medicine
Tecovirimat is available for the treatment of mpox (formerly known as monkeypox) in Europe and the United States, on the basis of findings from efficacy studies in animals and safety evaluations in healthy humans. Evidence from randomized, controlled trials of safety and efficacy in patients with mpox is lacking.We conducted a double-blind, randomized,
Rosine, Ali, Jules, Alonga, Jean-Luc, Biampata, Michael, Kombozi Basika, Irina, Maljkovic Berry, Nella, Bisento, Emily, Blum, Tyler, Bonnett, Katherine, Cone, Ian, Crozier, Richard, Davey, Ali, Dilu, Lori E, Dodd, Iman, Gulati, Dennis, Hruby, Augustin, Ibanda, Francis, Isse, Sylva Sivasingana, Kasareka, Gaby, Kayembe, Richard, Kojan, Esaie Kindombe, Luzolo, H Clifford, Lane, Leader, Lawanga, Laurens, Liesenborghs, Claude, Shosongo Lunghe, Yves, Lula, Mariano, Lusakibanza, Gaston Tona, Lutete, Placide, Mbala-Kingebeni, Alejandra, Miranda, Daniel, Mukadi-Bamuleka, Gael, Mukendi, Patrick Mutombo, Lupola, Jean-Jacques, Muyembe-Tamfum, Robin, Ndungunu, Bruce, Nganga, Nsengi, Ntamabyaliro, Veronique, Nussenblatt, Imoite, Omulepu, John, Omalokoho Onosomba, Michael, Proschan, Kevin, Rubenstein, Inga, Saknite, Adam, Schechner, Kathryn, Shaw-Saliba, Billy, Sivahera, Mary, Smolskis, Amy, Tillman, Eric, Tkaczyk, Celestin, Tshimanga, Olivier, Tshiani Mbaya, Antoine, Tshomba, Freddy, Yemba Unda Tshomba, David, Vallee, Susan, Vogel, Shera, Weyers   +55 more
openaire   +2 more sources

Three Neutralizing mAbs Induced by MPXV A29L Protein Recognizing Different Epitopes Act Synergistically Against Orthopoxvirus

Emerging Microbes and Infections, 2023
Jiayin Chen, Mengjun Li
exaly  

Development and Validation of a Nanoplate-Based Digital PCR Assay for Absolute MPXV Quantification

Journal of Virological Methods, 2023
Fabrizio Maggi, Claudia Minosse, Giulia Matusali   +2 more
exaly