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MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic–pituitary–adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis. Mutations in MC4R are the single most common cause of monogenic obesity.
Li F Chan +2 more
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MRAP2 regulates endometrial receptivity and function
Gene, 2019A successful embryo implantation depends on the synchronization between a competent blastocyst and a receptive endometrium. Recently, potential modulators of endometrial receptivity (OVGP1, MRAP2, ZCCHC12, and HAP1) have been reported likely with a functional role during embryo implantation.
Marco D'Aurora +2 more
exaly +4 more sources
Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish
Journal of Cellular Physiology, 2021AbstractThe melanocortin receptor accessory protein 2 (MRAP2) plays an essential role in the regulation of metabolic homeostasis and deletion of which results in severe obesity syndrome in mice and human. Mammalian MRAP2 is recognized as an endogenous physiological mediator through the potentiation of the MC4R signaling in vivo.
Meng Wang, Shaliu Fu, Chao Zhang
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Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling
Biochimica Et Biophysica Acta - Molecular Cell Research, 2017 The Melanocortin Receptor Accessory Protein 2 (MRAP2) regulates the activity of several GPCRs involved in the control of food intake and energy expenditure. While MRAP2 was originally thought to exclusively interact with melanocortin receptors we have recently shown that it interacts with and inhibits the trafficking and signaling of the prokineticin ...
Alix A J Rouault, Julien A Sebag
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Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension [PDF]
Nature Medicine, 2019 The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described in people with obesity1-3, their functional consequences on adiposity remain elusive.
Julien Philippe +2 more
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MC2R/MRAP2 activation could affect bovine ovarian steroidogenesis potential after ACTH treatment
Theriogenology, 2021Stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, reducing fertility by interfering with the mechanisms that regulate the timing of events within the follicular phase of the estrous cycle. In the HPA axis, melanocortin 2 receptor (MC2R) mediates responses to adrenocorticotropic hormone (ACTH) in concert with melanocortin receptor ...
L. Etchevers +7 more
openaire +3 more sources
Orange-spotted grouper melanocortin-4 receptor: Modulation of signaling by MRAP2
General and Comparative Endocrinology, 2019Melanocortin-4 receptor (MC4R) and melanocortin receptor accessory protein 2 (MRAP2) play important roles in the melanocortin system, and interaction of MC4R and MRAP2 is suggested to play pivotal role in energy balance of vertebrates. Orange-spotted grouper (Epinephelus coioides) is a widely cultured marine fish with high economic value in Asia.
Yong Zhang, Ya-Xiong Tao
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Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus) [PDF]
General and Comparative Endocrinology, 2021 Abstract The melanocortin-5 receptor (MC5R) has been implicated in the regulation of exocrine gland secretion, immune regulation, and muscle fatty acid oxidation. However, its function in fish is not well established. Melanocortin-2 receptor accessory protein 2 (MRAP2) can modulate trafficking, ligand binding, and signaling of ...
Ting Liu, Ya-Xiong Tao, Ti-Lin Yi
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