Results 151 to 160 of about 1,970 (167)

Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients

Eating and Weight Disorders, 2020
Monogenic forms of obesity are caused by single-gene variants which affect the energy homeostasis by increasing food intake and decreasing energy expenditure. Most of these variants result from disruption of the leptin-melanocortin signaling, which can cause severe early-onset obesity and hyperphagia.
Ana Carolina Proença da Fonseca, Verônica Marques Zembrzuski, Mário Campos Junior   +2 more
exaly   +3 more sources

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Pharmacology of orange-spotted grouper (Epinephelus coioides) melanocortin-5 receptor and its modulation by Mrap2

General and Comparative Endocrinology, 2023
The mammalian melanocortin-5 receptors (MC5Rs) are involved in various functions, including exocrine gland secretion, glucose uptake, adipocyte lipolysis, and immunity. However, the physiological role of fish Mc5r is rarely studied. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates pharmacological properties of melanocortin receptors ...
Li-Qin Ji, Ying-Zhu Rao, Yong Zhang, Rong Chen, Ya-Xiong Tao   +4 more
openaire   +2 more sources

The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a [PDF]

Science Signaling, 2020
An accessory protein suppresses β-arrestin–dependent signaling and constitutive activity of the ghrelin receptor.
Alix A J Rouault, Ciria C Hernandez, Luis E Gimenez   +2 more
exaly   +3 more sources

Identification of GLP1R and MCHR1 signaling as novel GPCR targets of MRAP2 protein

2022
The seven trans-membrane spanning G protein couple receptors(GPCRs) constitute the largest family of FDA approved drug targets to treat numerous human diseases, including metabolic associated disorders. The Melanocortin Receptor Accessory Protein 2 (MRAP2), a small single transmembrane protein broadly expressed in multiple tissues has been defined as a
Meng Wang, Jing Xu, Xiaowei Lei, Cong Zhang, Kuang Zhe, Haifeng Lan, Qingfen Li, Chao Zhang   +7 more
openaire   +1 more source

Abstract 003: Mrap2 Dissociate Mc4r-Mediated Sympathetic Control of Metabolism and Blood Pressure

Hypertension, 2018
The brain melanocortin-4 receptor (MC4R) plays an important in the control of food intake and energy expenditure by increasing thermogenic sympathetic nerve activity (SNA). In addition, brain MC4R-mediated activation of SNA subserving cardiovascular organs such as the kidneys increase blood pressure.
Deng-Fu Guo, Balyssa Bell, Donald A Morgan, Huxing Cui, Julien A Sebag, Kamal Rahmouni   +5 more
openaire   +1 more source

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)

Biomolecules, 2021
Zheng-Yong Wen, Ting Liu, Ya-Xiong Tao
exaly  

Melanocortin 2 receptor accessory protein 2 (MRAP2)

Science-Business eXchange, 2013
openaire   +1 more source

Loss of MRAP2 in MC4R neurons protect from obesity-associated autonomic and cardiovascular dysfunctions.

Cardiovascular research
The melanocortin receptor accessory protein 2 (MRAP2), which is abundantly expressed in the brain including the hypothalamus, has emerged as a key regulator of melanocortin-4 receptor (MC4R) activity. We sought to delineate the physiological significance of MRAP2 in MC4R neurons, with a particular focus on autonomic and cardiovascular functions ...
Deng Fu, Guo, Paul A, Williams, Alexis, Olson, Donald A, Morgan, Hussein, Herz, Jon, Resch, Deniz, Atasoy, Harald M, Stauss, Julien A, Sebag, Kamal, Rahmouni   +9 more
openaire   +1 more source

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

Science, 2013
Roger Cone, Chao Zhang, Roger D Cone
exaly  

MRAP2 a Novel Marker of Endometrial Receptivity?

2016
IMPICCIATORE, GIANNA GABRIELLA, Romani, F, FRANCHI, SARA, D'AURORA, MARCO, BUDANI, MARIA CRISTINA, Esposito, S, STUPPIA, Liborio, TIBONI, Gian Mario, GATTA, Valentina   +8 more
openaire   +1 more source