Results 1 to 10 of about 81,219 (271)
Renal Lesions in MRL Mice [PDF]
Veterinary Pathology, 1982 Female MRL-Mp- lpr/ lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG and complement component 3 (C3) barely were detectable.
Gerald J. Kolaja, Patricia Fast
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Discovery of a new class of integrin antibodies for fibrosis
Scientific Reports, 2021 Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types of cancer.
Ji Zhang +27 more
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MRL and SuperFine+MRL: new supertree methods [PDF]
Algorithms for Molecular Biology, 2012 Abstract Background Supertree methods combine trees on subsets of the full taxon set together to produce a tree on the entire set of taxa. Of the many supertree methods, the most popular is MRP (Matrix Representation with Parsimony), a method that operates by first encoding the input set of source trees by a large ...
Nguyen, Nam +2 more
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Structural insights into selective small molecule activation of PKG1α
Communications Biology, 2023 cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function.
Essam Metwally +17 more
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Scientific Reports, 2021 ApoEε4 is a major genetic risk factor for Alzheimer’s disease (AD), a disease hallmarked by extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs).
Angela Marie Jablonski +6 more
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Sjögren's syndrome in MRL/l and MRL/n mice [PDF]
Arthritis & Rheumatism, 1984 AbstractSix autoimmune murine models (MRL/l, MRL/n, NZB, NZB/NZW, PN, C57BL/6J‐lpr/lpr) were compared with normal control C57BL/6J and DBA/2 mice to determine if spontaneous autoimmune disease was associated with evidence of Sjögren's syndrome. Schirmer tests documented dry eyes in NZB/NZW and PN mice; other autoimmune strains and controls had normal ...
R W, Hoffman +4 more
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Band Keratopathy in MRL/1 and MRL/n Mice [PDF]
Arthritis & Rheumatism, 1983 AbstractTo define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/1, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp‐Ipr/lpr, C57BL/6J‐lpr/lpr, and normal control strains.
Hoffman, R W +5 more
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Nature Communications, 2021 Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both ...
Chuan Hong +21 more
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Vaccines, 2021 There is mounting evidence that the microbiome plays a critical role in training and maturation of the host immune system. Pre-clinical and clinical studies have shown that microbiome perturbation is correlated with sub-optimal host responses to vaccines
James E. Norton +5 more
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