Results 1 to 10 of about 2,344,036 (240)
Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats [PDF]
Animal Bioscience, 2022 Objective Spermatozoa are produced within the seminiferous tubules after sexual maturity. The expression levels of mRNAs and lncRNAs in testicular tissues are different at each stage of testicular development and are closely related to formation of the ...
Haolin Chen +7 more
doaj +1 more source
Functional Assays Combined with Pre-mRNA-Splicing Analysis Improve Variant Classification and Diagnostics for Individuals with Neurofibromatosis Type 1 and Legius Syndrome [PDF]
, 2023 Neurofibromatosis type 1 (NF1) and Legius syndrome (LS) are caused by inactivating variants in NF1 and SPRED1. NF1 encodes neurofibromin (NF), a GTPase-activating protein (GAP) for RAS that interacts with the SPRED1 product, Sprouty-related protein with ...
Douben, Hannie +17 more
core +2 more sources
mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
openaire +4 more sources
Integrative Analysis Of LncRNAs In Kidney Cancer To Discover A New LncRNA (LINC00847) As A Therapeutic Target For Staphylococcal Enterotoxin Tst Gene [PDF]
Cell Journal, 2020 Objective Bacterial toxin can cause cell death through induction of apoptosis in cancer cell lines as well as changes in the expression patterns of long non-coding RNAs (lncRNAs) and genes. In the present study, the effect of tst gene on ACHN cell lines
Maryam Safarpour-Dehkordi +2 more
doaj +1 more source
mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2013 We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Lynne E. Maquat +2 more
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mRNA distribution in skeletal muscle is associated with mRNA size [PDF]
Journal of Cell Science, 2021 ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
William Roman +8 more
openaire +3 more sources
Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts
Computational and Structural Biotechnology Journal, 2022 The process of translation initiation in prokaryotes is mediated by the hybridization of the 16S rRNA of the small ribosomal subunit with the mRNA in a short region called the ribosomal binding site. However, translation initiation in chloroplasts, which have evolved from an ancestral bacterium, is not well understood. Some studies suggest that in many
Stav Carmel Ezra, Tamir Tuller
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Vaccines, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection.
Frank Kowalzik +5 more
openaire +4 more sources
RNA Biology, 2013 The life of an mRNA molecule begins with transcription and ultimately ends in degradation. In the course of its life, however, mRNA is examined, modified in various ways and transported before eventually being translated into proteins. All these processes are performed by proteins and non-coding RNAs whose complex interplay in the cell contributes to ...
Denti, Michela Alessandra +4 more
openaire +3 more sources
mRNA Vaccine Platform: mRNA Production and Delivery
Russian Journal of Bioorganic Chemistry, 2023 Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
openaire +2 more sources