Results 1 to 10 of about 2,330,039 (349)

Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats [PDF]

open access: yesAnimal Bioscience, 2022
Objective Spermatozoa are produced within the seminiferous tubules after sexual maturity. The expression levels of mRNAs and lncRNAs in testicular tissues are different at each stage of testicular development and are closely related to formation of the ...
Haolin Chen   +7 more
doaj   +1 more source

Polyester materials for mRNA delivery

open access: yesExploration of Targeted Anti-tumor Therapy, 2022
Messenger RNA (mRNA) has recently made important progress in clinical implementation, offering a promising therapeutic option for infectious disease and cancer. However, the nature of mRNA molecules rendered them poorly bioavailable and unstable in vivo,
Wang Chen   +3 more
doaj   +1 more source

Integrative Analysis Of LncRNAs In Kidney Cancer To Discover A New LncRNA (LINC00847) As A Therapeutic Target For Staphylococcal Enterotoxin Tst Gene [PDF]

open access: yesCell Journal, 2020
Objective Bacterial toxin can cause cell death through induction of apoptosis in cancer cell lines as well as changes in the expression patterns of long non-coding RNAs (lncRNAs) and genes. In the present study, the effect of tst gene on ACHN cell lines
Maryam Safarpour-Dehkordi   +2 more
doaj   +1 more source

Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology [PDF]

open access: yesКлиническая практика, 2021
The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed.
Artem K. Aksamentov   +4 more
doaj   +1 more source

Increased Litter Size and Suckling Intensity Stimulate mRNA of RFamide-related Peptide in Rats [PDF]

open access: yesInternational Journal of Fertility and Sterility, 2015
Background RFamide-related peptide-3 (RFRP-3) inhibits gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in rats. This study evaluates the effects of litter size and suckling intensity on RFRP mRNA expression in the dorsomedial
Atefeh Noroozi   +4 more
doaj   +1 more source

Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation

open access: yesEndocrine Connections, 2020
B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of au toimmune B-cell expression profiles might enable a better understanding of GD pathogenesis.
Xuechao Jiang   +7 more
doaj   +1 more source

Identification of potential genes associated with immune cell infiltration in atherosclerosis

open access: yesMathematical Biosciences and Engineering, 2021
Background: This study aimed to analyze the potential genes associated with immune cell infiltration in atherosclerosis (AS). Methods: Gene expression profile data (GSE57691) of human arterial tissue samples were downloaded, and differentially ...
Xiaodong Xia   +6 more
doaj   +1 more source

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

open access: yesEmerging Microbes and Infections, 2022
Host circular RNAs (circRNAs) play critical roles in the pathogenesis of viral infections. However, how viruses modulate the biogenesis of host proviral circRNAs to facilitate their replication remains unclear.
Xi Zhang   +13 more
doaj   +1 more source

mRNA expression analysis of interleukins 17A and 17F in bronchial asthmatic patients from Northern Indian population

open access: yesJournal of Family Medicine and Primary Care, 2020
Introduction: Asthma being a chronic inflammatory disease concerning to the airways involves genetic and environmental factors. It is known to develop a clinical condition of airway hyper-responsiveness, which induces frequent symptoms in patients such ...
Rashmi Pandey, Ved Prakash
doaj   +1 more source

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

open access: yesNature Communications, 2017
The BioID approaches takes advantage of the promiscuous biotinylation enzyme (BirA*) to identify proteins that closely interact. Here the authors improve the resolution of BioID using a protein fragment complementation approach that allows the assignment
Isabel Myriam Schopp   +6 more
doaj   +1 more source

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