Lipid nanoparticles for mRNA delivery
Nature Reviews Materials, 2021 Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow ...
Xucheng Hou, Yi-Zhou Dong
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Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines [PDF]
npj VaccinesLipid nanoparticle (LNP) components can impact the safety and immunogenicity of mRNA vaccines. Here we examine the mechanisms contributing to the performance of mRNA-LNP vaccines by exploring the impact of nucleoside modifications and LNP components on ...
Hillary Danz +29 more
doaj +2 more sources
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Nature Reviews Drug Discovery, 2021 Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront ...
Namit Chaudhary, Kathryn A Whitehead
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SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
Nature, 2020 A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
Kizzmekia S Corbett +2 more
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Mammalian microRNAs predominantly act to decrease target mRNA levels
Nature, 2010 MicroRNAs (miRNAs) are endogenous ∼22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression.
Huili Guo +2 more
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mRNA vaccines — a new era in vaccinology
Nature Reviews Drug Discovery, 2018 Norbert Pardi, Michael J Hogan
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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
Nature Reviews Molecular Cell Biology, 2021 Lori Anne Passmore, Jeff Coller
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Post-transcriptional gene regulation by mRNA modifications
Nature Reviews Molecular Cell Biology, 2016 Boxuan Simen Zhao, Chuan He
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BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
New England Journal of Medicine, 2021 Background As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting.
N. Dagan +9 more
semanticscholar +1 more source
Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats [PDF]
Animal Bioscience, 2022 Objective Spermatozoa are produced within the seminiferous tubules after sexual maturity. The expression levels of mRNAs and lncRNAs in testicular tissues are different at each stage of testicular development and are closely related to formation of the ...
Haolin Chen +7 more
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