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mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
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mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2013 We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Lynne E. Maquat +2 more
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mRNA distribution in skeletal muscle is associated with mRNA size [PDF]
Journal of Cell Science, 2021 ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
William Roman +8 more
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Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts
Computational and Structural Biotechnology Journal, 2022 The process of translation initiation in prokaryotes is mediated by the hybridization of the 16S rRNA of the small ribosomal subunit with the mRNA in a short region called the ribosomal binding site. However, translation initiation in chloroplasts, which have evolved from an ancestral bacterium, is not well understood. Some studies suggest that in many
Stav Carmel Ezra, Tamir Tuller
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Vaccines, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection.
Frank Kowalzik +5 more
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RNA Biology, 2013 The life of an mRNA molecule begins with transcription and ultimately ends in degradation. In the course of its life, however, mRNA is examined, modified in various ways and transported before eventually being translated into proteins. All these processes are performed by proteins and non-coding RNAs whose complex interplay in the cell contributes to ...
Denti, Michela Alessandra +4 more
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mRNA Vaccine Platform: mRNA Production and Delivery
Russian Journal of Bioorganic Chemistry, 2023 Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
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Sensitivity of mRNA Translation [PDF]
Scientific Reports, 2015 AbstractUsing the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, elongation and termination rates along the mRNA strand on the steady-state protein translation rate.
Gilad Poker +2 more
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Industrial Psychiatry Journal, 2021 “Necessity is the mother of invention:” An adage was brought to life with the emergence of the mRNA vaccine against the backdrop of the foreboding and mercurial COVID-19 pandemic. Considering a negligible adverse-effect profile and a break-neck manufacturing speed, it shone bright as the ideal vaccine candidate.
AV Sowmya +4 more
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FEBS Letters, 2001 Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well coordinated processing steps, resulting in the formation of an export competent ribonucleoprotein complex (mRNP). Numerous factors involved in the translocation of the mRNP through the NPC and its release into the cytoplasm have been isolated mainly through genetic ...
Zenklusen, D, Stutz, Françoise
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