Results 1 to 10 of about 1,482,638 (100)

Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats [PDF]

open access: yesAnimal Bioscience, 2022
Objective Spermatozoa are produced within the seminiferous tubules after sexual maturity. The expression levels of mRNAs and lncRNAs in testicular tissues are different at each stage of testicular development and are closely related to formation of the ...
Haolin Chen   +7 more
doaj   +1 more source

Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology [PDF]

open access: yesКлиническая практика, 2021
The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed.
Artem K. Aksamentov   +4 more
doaj   +1 more source

MicroRNA: a clinician’s view of the state of the problem. Part 3: MicroRNA and approaches to the treatment of cardiovascular diseases

open access: yesЕвразийский Кардиологический Журнал, 2023
Cardiovascular diseases  are one of the most common  causes of death in both developing and developed countries of the world. Despite the improvement in primary prevention, the prevalence of cardiovascular diseases has continued to grow  in recent years.
O. Iu. Mironova   +3 more
doaj   +1 more source

Identification of Candidate mRNA Genes and Their Potential MicroRNA Targets in Lung Cancer Induced by Smoking Tobacco

open access: yesFrontiers in Bioscience-Scholar, 2023
Background: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer.
Amresh Kumar Mishra   +2 more
doaj   +1 more source

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

open access: yesNature Communications, 2017
In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize ...
Jérémy Dufourt   +9 more
doaj   +1 more source

Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation

open access: yesEndocrine Connections, 2020
B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of au toimmune B-cell expression profiles might enable a better understanding of GD pathogenesis.
Xuechao Jiang   +7 more
doaj   +1 more source

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

open access: yesNature Communications, 2017
The BioID approaches takes advantage of the promiscuous biotinylation enzyme (BirA*) to identify proteins that closely interact. Here the authors improve the resolution of BioID using a protein fragment complementation approach that allows the assignment
Isabel Myriam Schopp   +6 more
doaj   +1 more source

Polyester materials for mRNA delivery

open access: yesExploration of Targeted Anti-tumor Therapy, 2022
Messenger RNA (mRNA) has recently made important progress in clinical implementation, offering a promising therapeutic option for infectious disease and cancer. However, the nature of mRNA molecules rendered them poorly bioavailable and unstable in vivo,
Wang Chen   +3 more
doaj   +1 more source

Integrative Analysis Of LncRNAs In Kidney Cancer To Discover A New LncRNA (LINC00847) As A Therapeutic Target For Staphylococcal Enterotoxin Tst Gene [PDF]

open access: yesCell Journal, 2020
Objective Bacterial toxin can cause cell death through induction of apoptosis in cancer cell lines as well as changes in the expression patterns of long non-coding RNAs (lncRNAs) and genes. In the present study, the effect of tst gene on ACHN cell lines
Maryam Safarpour-Dehkordi   +2 more
doaj   +1 more source

Investigation of the anti-influenza activity of siRNA complexes against the cellular genes FLT4, Nup98, and Nup205 in vitro

open access: yesТонкие химические технологии, 2022
Objectives. Evaluation of changes in the viral activity of influenza A/WSN/33 after complex knockdown of combinations of cellular genes FLT4, Nup98 and Nup205 in human lung cell culture A549. Methods.
E. A. Pashkov   +13 more
doaj   +1 more source

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