Results 11 to 20 of about 2,522,941 (181)
mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2013 We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Gong, Chenguang +2 more
openaire +2 more sources
mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
openaire +3 more sources
mRNA Vaccine Platform: mRNA Production and Delivery
Russian Journal of Bioorganic Chemistry, 2023 Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
openaire +2 more sources
Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer. [PDF]
, 2014 IntroductionThe purpose of this study was to retrospectively explore the relationship between human epidermal growth factor receptor 2 (HER2) messenger RNA (mRNA) expression and efficacy in patients receiving trastuzumab plus docetaxel (HT) or ...
Amler, Lukas C +6 more
core +10 more sources
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]
, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
A Diaz +52 more
core +14 more sources
Vaccines, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection.
Frank Kowalzik +5 more
openaire +3 more sources
An agent-based model for mRNA export through the nuclear pore complex. [PDF]
, 2014 mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad +3 more
core +2 more sources
Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy [PDF]
, 2006 To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons.
Corps, AN +5 more
core +1 more source
, 1994 A myelopoiesis gene signature in circulating leucocytes, exemplified by increased myeloperoxidase (MPO) and proteinase 3 (PR3) mRNA levels, has been reported in patients with active anti-neutrophil cytoplasm antibody associated vasculitis (AAV) and to a ...
Basnet, Sandeep +5 more
core +2 more sources
High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer [PDF]
, 2019 DNA abnormalities are used in inclusion criteria of clinical trials for treatments with specific targeted molecules. MYC is one of the most powerful oncogenes and is known to be associated with triple-negative breast cancer (TNBC).
Dasgupta, Subhamoy +6 more
core +2 more sources