Results 11 to 20 of about 2,330,039 (349)
mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
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BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
New England Journal of Medicine, 2021 Background As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting.
N. Dagan +9 more
semanticscholar +1 more source
Lipid nanoparticles for mRNA delivery
Nature Reviews Materials, 2021 Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow ...
Xucheng Hou +3 more
semanticscholar +1 more source
A Comprehensive Review of mRNA Vaccines
International Journal of Molecular Sciences, 2023 mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing.
Vrinda Gote +6 more
semanticscholar +1 more source
mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2013 We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Lynne E. Maquat +2 more
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mRNA distribution in skeletal muscle is associated with mRNA size [PDF]
Journal of Cell Science, 2021 ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
William Roman +8 more
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Vaccines, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection.
Frank Kowalzik +5 more
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Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
New England Journal of Medicine, 2020 Background Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion ...
L. Baden +36 more
semanticscholar +1 more source
Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts
Computational and Structural Biotechnology Journal, 2022 The process of translation initiation in prokaryotes is mediated by the hybridization of the 16S rRNA of the small ribosomal subunit with the mRNA in a short region called the ribosomal binding site. However, translation initiation in chloroplasts, which have evolved from an ancestral bacterium, is not well understood. Some studies suggest that in many
Stav Carmel Ezra, Tamir Tuller
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
New England Journal of Medicine, 2020 Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic.
F. Polack +28 more
semanticscholar +1 more source