Results 21 to 30 of about 2,330,039 (349)
RNA Biology, 2013 The life of an mRNA molecule begins with transcription and ultimately ends in degradation. In the course of its life, however, mRNA is examined, modified in various ways and transported before eventually being translated into proteins. All these processes are performed by proteins and non-coding RNAs whose complex interplay in the cell contributes to ...
Denti, Michela Alessandra +4 more
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mRNA Vaccine Platform: mRNA Production and Delivery
Russian Journal of Bioorganic Chemistry, 2023 Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
New England Journal of Medicine, 2020 Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine.
L. Jackson +32 more
semanticscholar +1 more source
Myocarditis With COVID-19 mRNA Vaccines
Circulation, 2021 Supplemental Digital Content is available in the text. Myocarditis has been recognized as a rare complication of coronavirus disease 2019 (COVID-19) mRNA vaccinations, especially in young adult and adolescent males.
B. Bozkurt, I. Kamat, P. Hotez
semanticscholar +1 more source
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Nature reviews. Drug discovery, 2021 Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront ...
Namit Chaudhary +2 more
semanticscholar +1 more source
mRNA-based therapeutics: powerful and versatile tools to combat diseases
Signal Transduction and Targeted Therapy, 2022 The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the ...
Shugang Qin +10 more
semanticscholar +1 more source
Advances in COVID-19 mRNA vaccine development
Signal Transduction and Targeted Therapy, 2022 To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 deaths worldwide. COVID-19 is a serious threat to human health globally.
Enyue Fang +9 more
semanticscholar +1 more source
Industrial Psychiatry Journal, 2021 “Necessity is the mother of invention:” An adage was brought to life with the emergence of the mRNA vaccine against the backdrop of the foreboding and mercurial COVID-19 pandemic. Considering a negligible adverse-effect profile and a break-neck manufacturing speed, it shone bright as the ideal vaccine candidate.
AV Sowmya +4 more
openaire +4 more sources
SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness
Nature, 2020 A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
Kizzmekia S. Corbett +61 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Current messenger RNA (mRNA) vaccines in the clinic were reported to induce side effects in the liver, such as reversible hepatic damages and T cell–dominant immune-mediated hepatitis, which might be caused by the undesired expression of ...
Jinjin Chen +6 more
semanticscholar +1 more source