Results 31 to 40 of about 2,330,039 (349)
Sensitivity of mRNA Translation [PDF]
Scientific Reports, 2015 AbstractUsing the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, elongation and termination rates along the mRNA strand on the steady-state protein translation rate.
Gilad Poker +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The current application of messenger RNA (mRNA)-based technology has largely been confined to liver diseases because of the lack of a specific and efficient extrahepatic in vivo systemic mRNA delivery system.
Min Qiu +8 more
semanticscholar +1 more source
mRNA Metabolism and Hypertension
Biomedicines, 2023 Hypertension is the most frequent cardiovascular risk factor all over the world. It remains a leading contributor to the risk of cardiovascular events and death. In the year 2015, about 1.5 billion of adult people worldwide had hypertension (as defined by office systolic blood pressure ≥ 140 mmHg or office diastolic blood pressure ≥ 90 mmHg). Moreover,
Zappa M. +4 more
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piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm
Nature Communications, 2017 In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize ...
Jérémy Dufourt +9 more
doaj +1 more source
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
New England Journal of Medicine, 2020 Background Testing of vaccine candidates to prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an older population is important, since increased incidences of illness and death from coronavirus disease 2019 (Covid-19 ...
E. Anderson +36 more
semanticscholar +1 more source
FEBS Letters, 2001 Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well coordinated processing steps, resulting in the formation of an export competent ribonucleoprotein complex (mRNP). Numerous factors involved in the translocation of the mRNP through the NPC and its release into the cytoplasm have been isolated mainly through genetic ...
Zenklusen, D, Stutz, Françoise
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Cell Reports, 2015 The Piwi-interacting RNA (piRNA) pathway plays an essential role in the repression of transposons in the germline. Other functions of piRNAs such as post-transcriptional regulation of mRNAs are now emerging.
Bridlin Barckmann +11 more
doaj +1 more source
Cancer-testis genes in colon cancer [PDF]
Терапевтический архив, 2017 The expression of cancer-testis (CT) genes varies with tumor type. There are tumors with high, low, and intermediate gene expressions. Tumor cells of different origin are characterized by ST gene co-expression.
N R Hilal +3 more
doaj +1 more source
Journal of Molecular Endocrinology, 2000 The reverse transcription polymerase chain reaction (RT-PCR) is the most sensitive method for the detection of low-abundance mRNA, often obtained from limited tissue samples.
S. Bustin
semanticscholar +1 more source
, 2023 mRNA (messenger RNA) is a large class of single-stranded RNA molecules, and a blueprint for protein synthesis, transferring the genetic information from the DNA to the ribosome, where they specify the amino acid sequence of the protein product. During the movement of the ribosome along the mRNA, the base sequence on the mRNA is read and each three-base
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