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, 2023 mRNA (messenger RNA) is a large class of single-stranded RNA molecules, and a blueprint for protein synthesis, transferring the genetic information from the DNA to the ribosome, where they specify the amino acid sequence of the protein product. During the movement of the ribosome along the mRNA, the base sequence on the mRNA is read and each three-base
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Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation
Endocrine Connections, 2020 B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of au toimmune B-cell expression profiles might enable a better understanding of GD pathogenesis.
Xuechao Jiang +7 more
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Erratum: Corrigendum: mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2014 Nat. Struct. Mol. Biol. 20, 1214–1220 (2013); published online 22 September 2013; corrected after print 4 December 2013 In the version of this article initially published, the last sentence of the Figure 5 legend reads: “Downregulation of SOWAHC mRNA inhibits SOWAHC mRNA-CDCP1 mRNA base-pairing and thus the SOWAHC mRNA-mediated SMD of CDCP1 mRNA, an ...
Chenguang Gong +2 more
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Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]
, 2001 To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O. +6 more
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mRNA, a Revolution in Biomedicine [PDF]
Pharmaceutics, 2021 The perspective of using messenger RNA (mRNA) as a therapeutic molecule first faced some uncertainties due to concerns about its instability and the feasibility of large-scale production. Today, given technological advances and deeper biomolecular knowledge, these issues have started to be addressed and some strategies are being exploited to overcome ...
Bruno Baptista +4 more
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, 1994 A myelopoiesis gene signature in circulating leucocytes, exemplified by increased myeloperoxidase (MPO) and proteinase 3 (PR3) mRNA levels, has been reported in patients with active anti-neutrophil cytoplasm antibody associated vasculitis (AAV) and to a ...
Basnet, Sandeep +5 more
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Frontiers in Bioscience-Scholar, 2023 Background: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer.
Amresh Kumar Mishra +2 more
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Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice [PDF]
, 2010 The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions.
Mark R. Cookson +4 more
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Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma [PDF]
, 2010 BACKGROUND. MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription.
Alexe, Gabriela +13 more
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Journal of Family Medicine and Primary Care, 2020 Introduction: Asthma being a chronic inflammatory disease concerning to the airways involves genetic and environmental factors. It is known to develop a clinical condition of airway hyper-responsiveness, which induces frequent symptoms in patients such ...
Rashmi Pandey, Ved Prakash
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