Results 41 to 50 of about 2,330,039 (349)

mRNA, a Revolution in Biomedicine [PDF]

Pharmaceutics, 2021
The perspective of using messenger RNA (mRNA) as a therapeutic molecule first faced some uncertainties due to concerns about its instability and the feasibility of large-scale production. Today, given technological advances and deeper biomolecular knowledge, these issues have started to be addressed and some strategies are being exploited to overcome ...
Bruno Baptista, Rita Carapito, Nabila Laroui, Chantal Pichon, Fani Sousa   +4 more
openaire   +3 more sources

Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

Nature Cell Biology, 2018
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate.
Huilin Huang, Hengyou Weng, Wen-Ju Sun, Xi Qin, Hailing Shi, Huizhe Wu, B. Zhao, Ana Mesquita, Chang Liu, Celvie L. Yuan, Yueh-Chiang Hu, S. Hüttelmaier, Jennifer Skibbe, R. Su, Xiaolan Deng, Lei Dong, Miao Sun, Chenying Li, S. Nachtergaele, Yungui Wang, Chao Hu, Kyle Ferchen, K. Greis, Xi Jiang, M. Wei, Lianghu Qu, J. Guan, Chuan He, Jianhua Yang, Jianjun Chen   +29 more
semanticscholar   +1 more source

mRNA vaccine for cancer immunotherapy

Molecular Cancer, 2021
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune
Lei Miao, Yu Zhang, Leaf Huang
semanticscholar   +1 more source

Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021

MMWR. Morbidity and mortality weekly report, 2021
Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic COVID-19 in randomized placebo-controlled Phase III trials (1,2); however, the benefits of these vaccines ...
M. Thompson, J. Burgess, A. Naleway, Harmony L. Tyner, Sarang K. Yoon, J. Meece, Lauren E. W. Olsho, A. Caban-Martinez, A. Fowlkes, K. Lutrick, J. Kuntz, K. Dunnigan, M. Odean, K. Hegmann, Elisha L Stefanski, Laura J. Edwards, Natasha Schaefer-Solle, L. Grant, K. Ellingson, H. Groom, Tnelda Zunie, M. Thiese, L. Ivacic, Meredith G. Wesley, Julie Mayo Lamberte, Xiaoxiao Sun, Michael E. Smith, Andrew L. Phillips, Kimberly D. Groover, Young M. Yoo, J. Gerald, Rachel T. Brown, Meghan K Herring, G. Joseph, S. Beitel, Tyson Morrill, Josephine Mak, P. Rivers, K. Harris, D. Hunt, Melissa L. Arvay, P. Kutty, A. Fry, M. Gaglani   +43 more
semanticscholar   +1 more source

Erratum: Corrigendum: mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]

Nature Structural & Molecular Biology, 2014
Nat. Struct. Mol. Biol. 20, 1214–1220 (2013); published online 22 September 2013; corrected after print 4 December 2013 In the version of this article initially published, the last sentence of the Figure 5 legend reads: “Downregulation of SOWAHC mRNA inhibits SOWAHC mRNA-CDCP1 mRNA base-pairing and thus the SOWAHC mRNA-mediated SMD of CDCP1 mRNA, an ...
Chenguang Gong, Yalan Tang, Lynne E. Maquat   +2 more
openaire   +2 more sources

Heterogeneity in mRNA Translation [PDF]

Trends in Cell Biology, 2020
During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a ...
Sonneveld, Stijn, Verhagen, Bram M.P., Tanenbaum, Marvin E.   +2 more
openaire   +4 more sources

SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be
Raed Shalaby, Jacobus P. Petzer, Anél Petzer, Usman M. Ashraf, Ealla Atari, Fawaz Alasmari, Sivarajan Kumarasamy, Youssef Sari, Ashraf Khalil   +8 more
doaj   +1 more source

Mammalian microRNAs predominantly act to decrease target mRNA levels

Nature, 2010
MicroRNAs (miRNAs) are endogenous ∼22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression.
Huili Guo, Nicholas T. Ingolia, J. Weissman, D. Bartel   +3 more
semanticscholar   +1 more source

Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices — United States, June 2021

MMWR. Morbidity and mortality weekly report, 2021
In December 2020, the Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs) for the Pfizer-BioNTech COVID-19 (BNT162b2) vaccine and the Moderna COVID-19 (mRNA-1273) vaccine,† and the Advisory Committee on Immunization Practices ...
PhD Julia W. Gargano, DrPH Megan Wallace, MD Stephen C. Hadler, MD Gayle Langley, M. P. John R. Su, MD Matthew E. Oster, MD Karen R. Broder, Mph Julianne Gee, Mph Eric Weintraub, MD Tom Shimabukuro, PhD Heather M. Scobie, Mph Danielle Moulia, MD Lauri E. Markowitz, MD Melinda Wharton, JD Veronica V. McNally, MD José R. Romero, MD H. Keipp Talbot, MD Grace M. Lee, MD Matthew F. Daley, MD Sara E. Oliver   +19 more
semanticscholar   +1 more source

Synthetic mRNA capping [PDF]

Beilstein Journal of Organic Chemistry, 2017
Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparation – or a combination of both – can be advantageous.
Fabian Muttach, Nils Muthmann, Andrea Rentmeister   +2 more
openaire   +4 more sources