Results 41 to 50 of about 2,500,844 (367)
Stochastic mRNA production by a three-state gene [PDF]
arXiv, 2022 We consider a model of mRNA production governed by the dynamics of a gene that exists in three possible states -- inactive, poised and active. The transitions between the adjacent states are controlled by stochastic processes characterized by corresponding on/off rates.
arxiv
Beilstein Journal of Organic Chemistry, 2017 Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparation – or a combination of both – can be advantageous.
Fabian Muttach +2 more
openaire +4 more sources
Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity [PDF]
Nature (621), 396-403, 2023, 2020 Messenger RNA (mRNA) vaccines are being used for COVID-19, but still suffer from the critical issue of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine. Previous work showed that optimizing secondary structure stability lengthens mRNA half-life, which, together with optimal codons ...
arxiv +1 more source
Heterogeneity in mRNA Translation [PDF]
Trends in Cell Biology, 2020 During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a ...
Sonneveld, Stijn +2 more
openaire +4 more sources
High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer [PDF]
, 2019 DNA abnormalities are used in inclusion criteria of clinical trials for treatments with specific targeted molecules. MYC is one of the most powerful oncogenes and is known to be associated with triple-negative breast cancer (TNBC).
Dasgupta, Subhamoy +6 more
core +2 more sources
Human Vaccines & Immunotherapeutics, 2021 Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics ...
Filippos Filippatos +5 more
doaj +1 more source
Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene [PDF]
, 2004 Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits.
Baines, Richard A. +3 more
core +1 more source
Expression of Tau Protein and Tau mRNA in gastric carcinoma
Asian Journal of Medical Sciences, 2015 Aims and Objectives: To provide theoretical basis for the gastric carcinoma pathogenesis and the clinical targeted therapy. Materials and Methods: We detected the expression of Tau protein and Tau mRNA in 60 cases of gastric carcinoma tissues ...
Chun-hui Li
doaj +1 more source
Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]
, 2003 Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi +5 more
core +1 more source
VaccinesBackground: Although mRNA vaccines have the potential to be developed and deployed rapidly to combat infectious diseases, the ideal method of administration and boosting schedule strategy for generating optimal immunogenicity is an area of active ...
Bin Lu +14 more
doaj +1 more source