Results 51 to 60 of about 2,330,039 (349)

Identification of Candidate mRNA Genes and Their Potential MicroRNA Targets in Lung Cancer Induced by Smoking Tobacco

Frontiers in Bioscience-Scholar, 2023
Background: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer.
Amresh Kumar Mishra, Neha Mumtaz, Maneesh Kumar Misra   +2 more
doaj   +1 more source

Nanomaterial Delivery Systems for mRNA Vaccines

Vaccines, 2021
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as ...
M. Buschmann, Manuel J. Carrasco, Suman Alishetty, M. Paige, M. Alameh, D. Weissman   +5 more
semanticscholar   +1 more source

Impact of Extended Dosing Intervals and Ipsilateral Versus Contralateral Boosting on mRNA Vaccine Immunogenicity in Mice

Vaccines
Background: Although mRNA vaccines have the potential to be developed and deployed rapidly to combat infectious diseases, the ideal method of administration and boosting schedule strategy for generating optimal immunogenicity is an area of active ...
Bin Lu, Omkar Chaudhary, Balaji Banoth, Janhavi Nadkarni, Wei Zong, Emilie Mausser, Hillary Danz, Mona Motwani, Sophie Ruiz, Donghui Zhang, Gopinath Nageshwaran, Bachra Rokbi, William Warren, Frank DeRosa, Sudha Chivukula   +14 more
doaj   +1 more source

Association of clinical and epidemiological characteristics with COVID-19 BNT162b2 mRNA vaccine short-term adverse reactions in healthcare workers

Human Vaccines & Immunotherapeutics, 2021
Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics ...
Filippos Filippatos, Elizabeth-Barbara Tatsi, Charilaos Dellis, Nick Dessypris, Vassiliki Syriopoulou, Athanasios Michos   +5 more
doaj   +1 more source

AUGcontext DB: a comprehensive catalog of the mRNA AUG initiator codon context across eukaryotes

RNA Biology
The mRNA translation defines the composition of the cell proteome in all forms of life and diseases. In this process, precise selection of the mRNA translation initiation site (TIS) is crucial, as it establishes the correct open reading frame for triplet
Vincent G. Osnaya, Laura Gómez-Romero, Gabriel Moreno-Hagelsieb, Greco Hernández   +3 more
doaj   +1 more source

Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response

Cells, 2020
Tumor cell-derived extracellular vesicles (TEX) expressing tetraspanin Tspan8-alpha4/beta1 support angiogenesis. Tspan8-alpha6/beta4 facilitates lung premetastatic niche establishment.
Wei Mu, Jan Provaznik, Thilo Hackert, Margot Zöller   +3 more
doaj   +1 more source

Myc and mRNA capping

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015
c-Myc is upregulated in response to growth factors and transmits the signal to proliferate by altering the gene expression landscape. When genetic alterations result in growth factor-independent c-Myc expression, it can become an oncogene. The majority of human tumour types exhibit a degree of c-Myc deregulation, resulting in unrestrained cell ...
Dunn, Sianadh, Cowling, Victoria H.
openaire   +3 more sources

Cost-effectiveness analysis of COVID-19 booster vaccination with BNT162b2 in Japan

Expert Review of Vaccines
Background The aim of this study was to evaluate the public health and economic impact of the COVID-19 booster vaccination with BNT162b2 in Japan during an Omicron-dominant period from early 2022.Research design and methods A combined cohort Markov ...
Mitsuhiro Nagano, Kazumasa Kamei, Hiroyuki Matsuda, Chihiro Takahashi, Jingyan Yang, Koji Wada, Naohiro Yonemoto   +6 more
doaj   +1 more source

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

Infection and Drug Resistance, 2022
Xuewen Li,1 Yiting Wang,1 Qi Zhou,2 Junqi Pan,3 Jiancheng Xu1 1Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Pediatrics, First Hospital of Jilin University, Changchun, People ...
Li X, Wang Y, Zhou Q, Pan J, Xu J
doaj  

mRNA epitranscriptomics

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
openaire   +2 more sources