Results 61 to 70 of about 2,500,844 (367)

Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger [PDF]

, 2016
In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits ...
Akira, Akira, Akira, Alexopoulou, Allen, Anderson, Anderson, Andries, Angel, Auphan, Awe, Baba, Balachandran, Ballas, Banchereau, Bhattacharyya, Bonehill, Borden, Carroll, Chauhan, Clark, Coller, Conry, Courreges, Dewitte, Dewitte, Diebold, Diebold, Diken, Drews, El-Sayed, Fotin-Mleczek, Gallie, Garcia, George, Goubau, Grudzien-Nogalska, Gupta, Hacker, Halpern, Harii, Hartner, He, Heil, Heleen Dewitte, Heufler, Hoerr, Hornung, Hu, Ikeda, Ingrand, Israel, Jammi, Jha, Jha, Jirikowski, Joke Devoldere, Kallen, Kambara, Kanneganti, Kariko, Kariko, Kariko, Kariko, Kariko, Kariko, Katrien Remaut, Kawai, Kettle, Komuro, Kormann, Koski, Kreiter, Krieg, Krieg, Kumar, Kumar, Kuznik, Lee, Leonhardt, Li, Liniger, Loiarro, Lonez, Lorenz, Mandal, Mantovani, Martin, Martinon, Mays, Myskiw, Nallagatla, Nallagatla, Nekhai, Okumura, Pardi, Pascolo, Pascolo, Pathak, Pfaller, Pichlmair, Pichlmair, Pichlmair, Plews, Pollard, Qiu, Quintas-Cardama, Quintas-Cardama, Rajsbaum, Rejman, Rettig, Rothenfusser, Rowland, Sabbah, Sadler, Sahin, Samuel, Satoh, Scheel, Scheinman, Schlee, Schmidt, Schmolke, Schwartz, Sen, Silverman, Smith, Stefaan C. De Smedt, Sugiyama, Takahashi, Tang, Tavernier, Tavernier, Toshchakov, Tros de Ilarduya, Van Lint, Wang, Wang, Warren, Warren, Wells, Wolff, Xiang, Yakubov, Yamamoto, Yang, Yoneyama, Yoneyama, Yoshioka, Zangi, Zhu, Zhu, Zust   +152 more
core   +1 more source

Cost-effectiveness analysis of COVID-19 booster vaccination with BNT162b2 in Japan

Expert Review of Vaccines
Background The aim of this study was to evaluate the public health and economic impact of the COVID-19 booster vaccination with BNT162b2 in Japan during an Omicron-dominant period from early 2022.Research design and methods A combined cohort Markov ...
Mitsuhiro Nagano, Kazumasa Kamei, Hiroyuki Matsuda, Chihiro Takahashi, Jingyan Yang, Koji Wada, Naohiro Yonemoto   +6 more
doaj   +1 more source

An ensemble method to predict target genes and pathways in uveal melanoma

Open Life Sciences, 2018
This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The gene YEF3 function encoding translation elongation factor eEF3 is partially conserved across fungi

Frontiers in Microbiology
IntroductionTranslation is a fundamental process of life. In eukaryotes, the elongation step of translation is highly conserved and is driven by eukaryotic translation elongation factors (eEF)1A and eEF2.
Giovanna Maldonado, Alejandra García, Saturnino Herrero, Irene Castaño, Michael Altmann, Reinhard Fischer, Greco Hernández, Greco Hernández   +7 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The Development of mRNA Vaccines for Infectious Diseases: Recent Updates

Infection and Drug Resistance, 2021
Nitika,1,2 Jiao Wei,1,2 Ai-Min Hui1,2 1Fosun Pharma USA Inc., Boston, MA, USA; 2Shanghai Fosun Pharmaceutical Industrial Development, Co., Ltd., Shanghai, People’s Republic of ChinaCorrespondence: Ai-Min HuiShanghai Fosun Pharmaceutical Industrial ...
Nitika, Wei J, Hui AM
doaj  

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery

Nature Communications
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening.
Wei Wang, Kepan Chen, Ting Jiang, Yiyang Wu, Zheng Wu, Hang Ying, Hang Yu, Jing Lu, Jinzhong Lin, Defang Ouyang   +9 more
doaj   +1 more source