Results 61 to 70 of about 2,344,135 (339)
The Development of mRNA Vaccines for Infectious Diseases: Recent Updates
Infection and Drug Resistance, 2021 Nitika,1,2 Jiao Wei,1,2 Ai-Min Hui1,2 1Fosun Pharma USA Inc., Boston, MA, USA; 2Shanghai Fosun Pharmaceutical Industrial Development, Co., Ltd., Shanghai, People’s Republic of ChinaCorrespondence: Ai-Min HuiShanghai Fosun Pharmaceutical Industrial ...
Nitika, Wei J, Hui AM
doaj
4 open, 2019 It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
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Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]
, 2003 Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi +5 more
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Preferential Translation of mRNAs in an mRNA-Dependent Reticulocyte Lysate [PDF]
European Journal of Biochemistry, 1980 Messenger RNA competition experiments were performed in an mRNA-dependent reticulocyte lysate using three kinds of mRNA: rabbit globin mRNA, calf eye lens mRNA and RNA of turnip yellow mosaic virus. Our results indicate that at supersaturating concentrations of mRNA preferential translation of certain mRNA species can be observed.
Eline Meulenberg +3 more
openaire +3 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery
Nature CommunicationsLipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening.
Wei Wang +9 more
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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be
Raed Shalaby +8 more
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FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Identification of an Alternative Exon in a GABA Receptor Gene [PDF]
, 2018 The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed.
Apgar, Shannon, Toro, Cecilia P.
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The kinetic mechanism of bacterial ribosome recycling. [PDF]
, 2017 Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome.
Chen, Yuanwei +3 more
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