Results 81 to 90 of about 2,330,039 (349)
An ensemble method to predict target genes and pathways in uveal melanoma
Open Life Sciences, 2018 This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj +1 more source
Czech Journal of Animal Science, 2008 Skeletal muscle growth is determined by the number of prenatally formed fibres and by the degree of their postnatal hypertrophy; i.e. prenatal development may influence the postnatal growth.
K. Bílek +7 more
doaj +1 more source
Expression of long non-coding RNA and mRNA in the hippocampus of mice with type 2 diabetes
Molecular Medicine Reports, 2018 Long non-coding RNAs (lncRNAs) serve key roles in cell growth, development and various diseases associated with the central nervous system. However, differential expression profiles of lncRNAs in type 2 diabetes have not been reported.
L. Ci +7 more
semanticscholar +1 more source
Insights into the mRNA Cleavage Mechanism by MazF, an mRNA Interferase [PDF]
Journal of Biological Chemistry, 2005 MazF is an Escherichia coli toxin that is highly conserved among the prokaryotes and plays an important role in growth regulation. When MazF is induced, protein synthesis is effectively inhibited. However, the mechanism of MazF action has been controversial.
Yonglong Zhang +4 more
openaire +3 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
mRNA therapeutics in cancer immunotherapy
Molecular Cancer, 2021 Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical applications, including different modalities of cancer immunotherapy. With the ease of rapid, large
Jan D. Beck +6 more
semanticscholar +1 more source
Genome-wide mRNA surveillance is coupled to mRNA export [PDF]
Genes & Development, 2004 Nuclear export of mRNA is a central step in gene expression that shows extensive coupling to transcription and transcript processing. However, little is known about the fate of mRNA and its export under conditions that damage the DNA template and RNA itself.
Pamela A. Silver +2 more
openaire +3 more sources
mRNA ageing shapes the Cap2 methylome in mammalian mRNA
Nature, 2023 The mRNA cap structure is a major site of dynamic mRNA methylation. mRNA caps exist in either the Cap1 or Cap2 form, depending on the presence of 2'-O-methylation on the first transcribed nucleotide or both the first and second transcribed nucleotides, respectively1,2. However, the identity of Cap2-containing mRNAs and the function of Cap2 are unclear.
Vladimir Despic, Samie R. Jaffrey
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ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
The Journal of Cell Biology, 2003 ![Graphic][1] P bodies proliferate when mRNA degradation is blocked (right). Parker/AAASAnother day, another organelle. Cytoplasmic foci of various mRNA processing enzymes have now been confirmed by Ujwal Sheth and Roy Parker (University of Arizona, Tucson, AZ) as functional ...
openaire +2 more sources