Results 1 to 10 of about 1,826,319 (224)
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP [PDF]
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
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Nature Communications, 2022 Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Shiladitya Chattopadhyay +15 more
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease [PDF]
Nature Communications, 2017 “mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability
Rached Alkallas +3 more
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Cellular variability of nonsense-mediated mRNA decay
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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ZFP36-mediated mRNA decay regulates metabolism
Cell Reports, 2023 Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have ...
Andrew C. Cicchetto +11 more
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Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity
Cell Reports, 2019 Summary: Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive.
Xiao Yu +8 more
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Cell ReportsSummary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more ...
Alicia A. Bicknell +15 more
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Nonsense-mediated mRNA Decay and Cancer.
Current Opinion in Genetics & Development, 2018 Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key
M. W. Popp, L. Maquat
semanticscholar +4 more sources
Extensive reshaping of bacterial operons by programmed mRNA decay. [PDF]
PLoS Genetics, 2018 Bacterial operons synchronize the expression of multiple genes by placing them under the control of a shared promoter. It was previously shown that polycistronic transcripts can undergo differential RNA decay, leaving some genes within the polycistron ...
Daniel Dar, Rotem Sorek
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Uridylation regulates mRNA decay directionality in fission yeast [PDF]
Nature CommunicationsCytoplasmic mRNA decay is effected by exonucleolytic degradation in either the 5’ to 3’ or 3’ to 5’ direction. Pervasive terminal uridylation is implicated in mRNA degradation, however, its functional relevance for bulk mRNA turnover remains poorly ...
Maciej Grochowski +9 more
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