Results 81 to 90 of about 1,826,338 (237)

Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events [PDF]

, 2018
Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression.
Besso, María José, Furlong, Laura Ines, Giustina, Silvina, Lapyckyj, Lara, Marin Briggiler, Clara Isabel, Matos, María Laura, Mencucci, Maria Victoria, Rosso, Marina, Vazquez, Monica Hebe   +8 more
core   +1 more source

Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay

Molecules and Cells, 2019
Summary Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease.
Tim A. Hoek, D. Khuperkar, Rik G. H. Lindeboom, Stijn Sonneveld, B. M. Verhagen, S. Boersma, M. Vermeulen, M. Tanenbaum   +7 more
semanticscholar   +1 more source

mRNA Degradation and Decay [PDF]

, 2014
Why is it important to understand mRNA degradation in a cell? First,RNA degradation has a clearing function and removes RNAs arising from tran-scription, splicing, export, or translation “accidents” to ensure robust geneexpression (see Chap. 8). Second, while regulation of gene expression has a veryimportant transcription component, mRNAs must be ...
Fromont-Racine, Micheline, Saveanu, Cosmin   +1 more
openaire   +2 more sources

Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries

Viruses, 2016
The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given the presence of retained introns and instability AU-rich sequences, this viral transcript
Daniela Toro-Ascuy, Bárbara Rojas-Araya, Fernando Valiente-Echeverría, Ricardo Soto-Rifo   +3 more
doaj   +1 more source

Monitoring mRNA Half-Life in Arabidopsis Using Droplet Digital PCR

Plants, 2022
mRNA decay is an important process in post-transcriptional regulation; in addition, it plays a crucial role in plant development and response to stress.
Alexandre Boubegtitene, Rémy Merret
doaj   +1 more source

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources

Dynamics of gene expression and the regulatory inference problem

, 2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
, Alon U., Chen W. England J. Shakhnovich E., Hertz J., Honerkamp J., J. Berg, Lèbre S., Michaelis L., Spellman P. T., Stokic D. Hanel R. Thurner S., van Kampen N.   +10 more
core   +1 more source

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

BR-bodies provide selectively permeable condensates that stimulate mRNA decay and prevent release of decay intermediates

bioRxiv, 2019
Biomolecular condensates play a key role in organizing RNAs and proteins into membraneless organelles. Bacterial RNP-bodies (BR-bodies) are a biomolecular condensate containing the RNA degradosome mRNA decay machinery, but the biochemical function of ...
N. Al-Husini, Dylan T. Tomares, Zechariah Pfaffenberger, N. Muthunayake, M. A. Samad, Tiancheng Zuo, O. Bitar, J. Aretakis, Mohammed-Husain M. Bharmal, Alisa Gega, J. Biteen, W. S. Childers, Jared M. Schrader   +12 more
semanticscholar   +1 more source

CELFish ways to modulate mRNA decay [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
The CELF family of RNA-binding proteins regulates many steps of mRNA metabolism. Although their best characterized function is in pre-mRNA splice site choice, CELF family members are also powerful modulators of mRNA decay. In this review we focus on the different modes of regulation that CELF proteins employ to mediate mRNA decay by binding to GU-rich ...
Irina, Vlasova-St Louis, Alexa M, Dickson, Paul R, Bohjanen, Carol J, Wilusz   +3 more
openaire   +2 more sources