Results 241 to 250 of about 3,806,370 (293)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

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mRNA processing in the Trypanosomatidae

Experientia, 1991
Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world.
K, Perry, N, Agabian
openaire   +2 more sources

Pre-mRNA processing and mRNA nuclear export

Current Opinion in Cell Biology, 1989
The primary transcript of a prokaryotic gene is translated immediately following or during synthesis, whereas in eukaryotes, messenger RNA (mRNA) precursors (premRNAs) are synthesized in the nucleus and are then structurally altered and relocated to the cytoplasm before translation (Fig. 1).
openaire   +2 more sources

Control of mRNA processing and decay in prokaryotes

Genetica, 1994
Post-transcriptional mechanisms operate in regulation of gene expression in bacteria, the amount of a given gene product being also dependent on the inactivation rate of its own message. Moreover, segmental differences in mRNA stability of polycistronic transcripts may be responsible for differential expression of genes clustered in operons.
ALIFANO, Pietro, BRUNI CB, CARLOMAGNO MS
openaire   +4 more sources

mRNA processing in Antonospora locustae spores

Molecular Genetics and Genomics, 2008
Microsporidia are a group of intracellular parasites characterized by highly reduced and compact genomes. The presence of a high gene density had several consequences for microsporidian genomes, including a high frequency of overlap between transcripts of adjacent genes. This phenomenon is apparently widespread in microsporidia, and strongly correlated
Nicolas, Corradi, Lena, Burri, Patrick J, Keeling   +2 more
openaire   +2 more sources

Targeting mRNA processing as an anticancer strategy

Nature Reviews Drug Discovery, 2019
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations, alterations in mRNA can contribute to the initiation and progression of cancer.
Desterro, Joana, Bak-Gordon, Pedro, Carmo-Fonseca, Maria   +2 more
openaire   +3 more sources

Processing of Adenovirus Nuclear RNA to mRNA

1981
Publisher Summary The mechanism, as well as the regulation, of the biogenesis of adenovirus messenger RNA (mRNA) has been the subject of intensive research over the past several years, principally because it provides an excellent model for the events that occur in the uninfected mammalian cell.
J R, Nevins, S, Chen-Kiang
openaire   +2 more sources

Proteome Analysis of Chloroplast mRNA Processing and Degradation

Journal of Proteome Research, 2006
Chloroplasts have a complex enzymatic machinery to adjust the relative half-life of their mRNAs to environmental signals. Soluble protein extracts from spinach (Spinacia oleracea L.) chloroplasts that correctly reproduce in vitro the differential mRNA stability observed in vivo were analyzed using shotgun proteomics to identify the proteins that are ...
Baginsky, S, Grossmann, J, Gruissem, W
openaire   +3 more sources

Nuclear organization of pre-mRNA processing

Current Opinion in Cell Biology, 1993
Recent studies have suggested that small nuclear ribonucleoprotein particles (snRNPs), non-snRNP splicing factors, and several heterogeneous nuclear RNP proteins change their organization within the cell in response to transcriptional activity. Several of the RNA substrates with which these factors interact have been shown to localize in tracks that ...
openaire   +2 more sources