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mRNA Decay and Processing

2014
Since there have been several extensive reviews of mRNA decay within the last several years, this chapter focuses on issues that have not been completely resolved. These include the importance of RNA structural elements in mRNA decay, the existence and function of multiprotein mRNA decay complexes, the role of polyadenylation in mRNA decay, the ...
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Eukaryotic mRNA Processing

1997
Abstract This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in ...
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Mutual relationships between transcription and pre‐mRNA processing in the synthesis of mRNA

WIREs RNA, 2012
AbstractThe generation of messenger RNA (mRNA) in eukaryotes is achieved by transcription from the DNA template and pre‐mRNA processing reactions of capping, splicing, and polyadenylation. Although RNA polymerase II (RNAPII) catalyzes the synthesis of pre‐mRNA, it also serves as a principal coordinator of the processing reactions in the course of ...
Tina, Lenasi, Matjaz, Barboric
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Control of transcription and mRNA processing

1986
An organism must be able to modulate the expression of its genes. Some proteins, such as the enzymes of key metabolic pathways and the ribosomal proteins, will be required in large quantities. Thus, in an E. coli cell it has been calculated that there are 20 000 ribosomes so it follows that there will be at least 20 000 copies of each of their ...
Roger L. P. Adams   +2 more
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mRNA processing and genomic instability

Nature Structural & Molecular Biology, 2005
A new study adds to our understanding of the interconnection between different nuclear processes by showing that a 'classical' metazoan precursor mRNA–processing factor functions to prevent transcription-associated genomic instability.
openaire   +1 more source

3′-End Processing of Eukaryotic mRNA: Machinery, Regulation, and Impact on Gene Expression

Annual Review of Biochemistry, 2023
Lori Anne Passmore, Vytaute Boreikaite
exaly  

Mpe1 senses the binding of pre-mRNA and controls 3′ end processing by CPF

Molecular Cell, 2022
Juri Rappsilber   +2 more
exaly  

Mutations that affect mRNA synthesis, processing and translation

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2021
Dirk Roos, Martin de Boer
exaly  

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