Results 21 to 30 of about 19,056,956 (378)
A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the Drosophila egg. [PDF]
J Cell Sci, 2021 Potter-Birriel JM +2 more
europepmc +2 more sources
Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulence. [PDF]
NAR Mol MedScholl A +8 more
europepmc +3 more sources
Integrating mRNA Processing with Transcription [PDF]
Cell, 2002 The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout ...
N. Proudfoot, A. Furger, M. Dye
semanticscholar +4 more sources
Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
doaj +1 more source
Aberrant pre-mRNA processing in cancer. [PDF]
J Exp MedDysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies.
Biswas J +3 more
europepmc +3 more sources
Crosstalk Between mRNA 3'-End Processing and Epigenetics
Frontiers in Genetics, 2021 The majority of eukaryotic genes produce multiple mRNA isoforms by using alternative poly(A) sites in a process called alternative polyadenylation (APA).
Lindsey V. Soles, Yongsheng Shi
doaj +1 more source
Frontiers in Genetics, 2021 HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In
Georges Khoury +9 more
doaj +1 more source
Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites
Cells, 2020 Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence ...
Katharina Frey, Boas Pucker
doaj +1 more source
Systems perspectives on mRNA processing [PDF]
Cell Research, 2007 The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after transcription. Large-scale systems analyses of mRNA-protein interactions and mRNA dynamics have revealed specificity in mRNA transcription, splicing, transport ...
Adrienne E, McKee, Pamela A, Silver
openaire +2 more sources
Nutritional Regulation of mRNA Processing [PDF]
The Journal of Nutrition, 2004 Understanding how a cell adapts to dietary energy in the form of carbohydrate versus energy in the form of triacylglycerol requires knowledge of how the activity of the enzymes involved in lipogenesis is regulated. Changes in the activity of these enzymes are largely caused by changes in the rate at which their proteins are synthesized.
Lisa M, Salati +6 more
openaire +2 more sources