Results 21 to 30 of about 18,476,439 (363)
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. [PDF]
Mol Cell, 2022 Martinez NM +7 more
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Oncogenic dysregulation of pre-mRNA processing by protein kinases: challenges and therapeutic opportunities. [PDF]
FEBS J, 2021 Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐processing, which ensure proper gene expression and diversification of human transcriptomes.
Naro C, Bielli P, Sette C.
europepmc +2 more sources
Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond. [PDF]
Front Cell Dev Biol, 2021 Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3, 4,
Yang C +10 more
europepmc +2 more sources
Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
doaj +1 more source
Crosstalk Between mRNA 3'-End Processing and Epigenetics
Frontiers in Genetics, 2021 The majority of eukaryotic genes produce multiple mRNA isoforms by using alternative poly(A) sites in a process called alternative polyadenylation (APA).
Lindsey V. Soles, Yongsheng Shi
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The process of mRNA–tRNA translocation [PDF]
Proceedings of the National Academy of Sciences, 2007 In the elongation cycle of translation, translocation is the process that advances the mRNA–tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during ...
Ning Gao +4 more
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Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription [PDF]
Genes & Development, 2000 The activities of several mRNA processing factors are coupled to transcription through binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive carboxy-terminal domain (CTD) that becomes highly phosphorylated during ...
Philip Komarnitsky +2 more
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Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites
Cells, 2020 Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence ...
Katharina Frey, Boas Pucker
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Frontiers in Genetics, 2021 HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In
Georges Khoury +9 more
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Systems perspectives on mRNA processing [PDF]
Cell Research, 2007 The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after transcription. Large-scale systems analyses of mRNA-protein interactions and mRNA dynamics have revealed specificity in mRNA transcription, splicing, transport ...
Adrienne E McKee, Pamela A. Silver
openaire +3 more sources