Results 11 to 20 of about 637 (211)
Pre-mRNA secondary structures influence exon recognition. [PDF]
PLoS Genetics, 2007 The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding ...
Michael Hiller +3 more
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Secondary structure of a conserved domain in the intron of influenza A NS1 mRNA. [PDF]
PLoS ONE, 2013 Influenza A virus is a segmented single-stranded (-)RNA virus that causes substantial annual morbidity and mortality. The transcriptome of influenza A is predicted to have extensive RNA secondary structure. The smallest genome segment, segment 8, encodes
Salvatore F Priore +6 more
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On the role of mRNA secondary structure in bacterial translation [PDF]
WIREs RNA, 2019 AbstractMessenger RNA (mRNA) is no longer considered as a mere informational molecule whose sole function is to convey the genetic information specified by DNA to the ribosome. Beyond this primary function, mRNA also contains additional instructions that influence the way and the extent to which this message is translated by the ribosome into protein(s)
Claude Chiaruttini, Maude Guillier
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Volatility in mRNA secondary structure as a design principle for antisense [PDF]
Nucleic Acids Research, 2012 Designing effective antisense sequences is a formidable problem. A method for predicting efficacious antisense holds the potential to provide fundamental insight into this biophysical process. More practically, such an understanding increases the chance of successful antisense design as well as saving considerable time, money and labor.
Johnson, Erik, Srivastava, Ranjan
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Global or local? Predicting secondary structure and accessibility in mRNAs [PDF]
Nucleic Acids Research, 2012 Determining the structural properties of mRNA is key to understanding vital post-transcriptional processes. As experimental data on mRNA structure are scarce, accurate structure prediction is required to characterize RNA regulatory mechanisms. Although various structure prediction approaches are available, it is often unclear which to choose and how to
Saunders, Sita Johanna +5 more
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Mechanism of ribosome translation through mRNA secondary structures [PDF]
International Journal of Biological Sciences, 2017 A ribosome is a macromolecular machine that is responsible for translating the genetic codes in messenger RNA (mRNA) into polypeptide chains. It has been determined that besides translating through the single-stranded region, the ribosome can also translate through the duplex region of mRNA by unwinding the duplex.
Xie, Ping, Chen, Hong
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Genomics, Proteomics & Bioinformatics, 2021 Abstract The secondary structure is a fundamental feature of both non-coding RNAs (ncRNAs) and messenger RNAs (mRNAs). However, our understanding of the secondary structures of mRNAs, especially those of the coding regions, remains elusive, likely due to translation and the lack of RNA-binding proteins that sustain the consensus ...
Gongwang Yu +3 more
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Maintenance of pre-mRNA secondary structure by epistatic selection. [PDF]
Proceedings of the National Academy of Sciences, 1995 Linkage disequilibrium between polymorphisms in a natural population may result from various evolutionary forces, including random genetic drift due to sampling of gametes during reproduction, restricted migration between subpopulations in a subdivided population, or epistatic selection.
Kirby, David A. +2 more
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Are synonymous codons indeed synonymous?
Biomolecular Concepts, 2012 It has long been known that the distribution and frequency of occurence of synonymous codons can vary greatly among different species, and that the abundance of isoaccepting tRNA species could also be very different.
Venetianer Pál
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Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
eLife, 2017 Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold.
David H Burkhardt +5 more
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