Results 21 to 30 of about 637 (211)
Frontiers in Cellular and Infection Microbiology, 2021 It is widely accepted that the structure of RNA plays important roles in a number of biological processes, such as polyadenylation, splicing, and catalytic functions. Dynamic changes in RNA structure are able to regulate the gene expression programme and
Yanwei Qi +8 more
doaj +1 more source
PLoS Computational Biology, 2010 Recent studies have suggested that the thermodynamic stability of mRNA secondary structure near the start codon can regulate translation efficiency in Escherichia coli, and that translation is more efficient the less stable the secondary structure.
Wanjun Gu, Tong Zhou, Claus O Wilke
doaj +1 more source
Reduced stability of mRNA secondary structure near the translation-initiation site in dsDNA viruses
BMC Evolutionary Biology, 2011 Background Recent studies have demonstrated a selection pressure for reduced mRNA secondary-structure stability near the start codon of coding sequences.
Wilke Claus O, Zhou Tong
doaj +1 more source
Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing. [PDF]
PLoS ONE, 2013 We previously reported that the distribution of fitness effects for non-synonymous and synonymous mutations in Salmonella typhimurium ribosomal proteins S20 and L1 are similar, suggesting that fitness constraints are present at the level of mRNA. Here we
Peter A Lind, Dan I Andersson
doaj +1 more source
Unfolding of mRNA Secondary Structure by the Bacterial Translation Initiation Complex [PDF]
Molecular Cell, 2006 Translation initiation is a key step for regulating the level of numerous proteins within the cell. In bacteria, the 30S initiation complex directly binds to the translation initiation region (TIR) of the mRNA. How the ribosomal 30S subunit assembles on highly structured TIR is not known.
Studer, Sean M., Joseph, Simpson
openaire +2 more sources
Secondary structures in RNA synthesis, splicing and translation
Computational and Structural Biotechnology Journal, 2022 Even though the functional role of mRNA molecules is primarily decided by the nucleotide sequence, several properties are determined by secondary structure conformations. Examples of secondary structures include long range interactions, hairpins, R-loops
Ilias Georgakopoulos-Soares +2 more
doaj +1 more source
Influence of RNA Secondary Structure on the Pre-mRNA Splicing Process [PDF]
Molecular and Cellular Biology, 2004 Pre-mRNA splicing in eukaryotes requires joining together the nucleotides of the various mRNA-coding regions (exons) after recognizing them from the normally vastly superior number of non-mRNA-coding sequences (introns). For three excellent reviews on general splicing and its regulation, refer to references 14, 62, and 70.
Emanuele, Buratti, Francisco E, Baralle
openaire +2 more sources
Secondary structure of splice sites in adenovirus mRNA precursors [PDF]
Nucleic Acids Research, 1984 In order to investigate the possible role of RNA secondary structure in determining the efficiency and specificity of mRNA splicing, the structures of sequences at three acceptor splice sites in adenovirus were studied. Transcripts spanning intron-exon junctions were synthesized using SP6 RNA polymerase and analyzed using single and double-strand ...
openaire +2 more sources
A periodic pattern of mRNA secondary structure created by the genetic code [PDF]
Nucleic Acids Research, 2006 Single-stranded mRNA molecules form secondary structures through complementary self-interactions. Several hypotheses have been proposed on the relationship between the nucleotide sequence, encoded amino acid sequence and mRNA secondary structure. We performed the first transcriptome-wide in silico analysis of the human and mouse mRNA foldings and found
Shabalina, Svetlana A. +2 more
openaire +2 more sources
Determination of secondary structure in the initiation region of ovalbumin mRNA
Nucleic Acids Research, 1988 We have analyzed the secondary structure in the region surrounding the initiation codons of both cellular and synthetic versions of ovalbumin mRNA. RNase V1 cleavage sites and structure-dependent, chemically modified bases in cellular ovalbumin mRNA were determined by reverse transcription of hen poly A(+) RNA using ovalbumin-specific, synthetic DNA ...
C D, Liarakos +5 more
openaire +3 more sources