Results 181 to 190 of about 4,875 (208)
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5′-Terminal structure and mRNA stability
Nature, 1977Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from ...
Y, Furuichi, A, LaFiandra, A J, Shatkin
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Connections Underlying Translation and mRNA Stability
Journal of Molecular Biology, 2016Gene expression and regulation in organisms minimally depends on transcription by RNA polymerase and on the stability of the RNA product (for both coding and non-coding RNAs). For coding RNAs, gene expression is further influenced by the amount of translation by the ribosome and by the stability of the protein product.
Aditya, Radhakrishnan, Rachel, Green
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1992
Abstract The level of an mRNA in the cell is determined both by its rate of synthesis and by its rate of decay. Since mRNA half-lives range from about 1 min to over 1 h in the yeast, Saccharomyces cerevisiae (1–4), differential rates of mRNA decay have a fundamental influence upon the overall pattern of protein synthesis in this model
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Abstract The level of an mRNA in the cell is determined both by its rate of synthesis and by its rate of decay. Since mRNA half-lives range from about 1 min to over 1 h in the yeast, Saccharomyces cerevisiae (1–4), differential rates of mRNA decay have a fundamental influence upon the overall pattern of protein synthesis in this model
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Hypoxia-Induced Regulation of mRNA Stability
2002Because molecular oxygen is essential for generating cellular energy in aerobic organisms, and because survival depends on this fundamental requirement for oxygen, all higher organisms have evolved numerous diversely regulated mechanisms to detect and respond to potentially life-threatening occurrences of decreased oxygen availability (hypoxia).
W R, Paulding, M F, Czyzyk-Krzeska
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Evaluating the Stability of mRNAs and Noncoding RNAs
2016Changes in RNA stability have an important impact in the gene expression regulation. Different methods based on the transcription blockage with RNA polymerase inhibitors or metabolic labeling of newly synthesized RNAs have been developed to evaluate RNA decay rates in cultured cell.
Ana Carolina, Ayupe, Eduardo M, Reis
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mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
International Journal of Pharmaceutics, 2021Linde Schoenmaker +2 more
exaly
mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
Molecular Cell, 2023Marina Chekulaeva
exaly
REGULATION OF mRNA STABILITY IN DEVELOPMENT
Annual Review of Genetics, 1994P, Surdej, A, Riedl, M, Jacobs-Lorena
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Condition-specific 3′ mRNA isoform half-lives and stability elements in yeast
Proceedings of the National Academy of Sciences of the United States of America, 2023Joseph V Geisberg +2 more
exaly