Results 91 to 100 of about 110,071 (192)

mRNA vaccines: A matter of delivery [PDF]

EClinicalMedicine, 2021
Cao, Yuhong, Gao, George F.
openaire   +3 more sources

Immunogenicity of HIV-1 Env mRNA and Env-Gag VLP mRNA Vaccines in Mice

Background: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic. Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins.
Yanzhe Hao, Xia Feng, Qi Ma, Jing Yang, Hongxia Li, Xiaoguang Zhang   +5 more
core   +1 more source

Emerging prospects of mRNA cancer vaccines: mechanisms, formulations, and challenges in cancer immunotherapy

Frontiers in Immunology
Cancer continues to pose an alarming threat to global health, necessitating the need for the development of efficient therapeutic solutions despite massive advances in the treatment. mRNA cancer vaccines have emerged as a hopeful avenue, propelled by the
Umm E. Laila, Wang An, Zhi-Xiang Xu
doaj   +1 more source

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection

Background: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein–Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human ...
Haikun Wang, Zhuang Wang, Linlin Kuang, Shuxia Wang, Xiaozhen Liang, Zhong Huang, Ning Li, Yannan Yin, Jinkai Zang, Huichun Shi   +9 more
core   +1 more source

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2

npj Vaccines
The COVID-19 pandemic spurred mRNA vaccine innovation, but new SARS-CoV-2 variants highlight the need for vaccines with improved potency and durability.
Jason P. Laliberte, Yingyun Cai, Tara Kenny, Yi Zhang, Kuishu Ren, Kim Rosenthal, Daniel Flores, Richard Roque, Oliver Acton, Vanessa Cadevilla Peano, Noel Janney, Vinita Puri, Sarah Siddiqui, Angela Pack, Giune Padilla, Seme Diallo, Hibret Adissu, Rakesh Choudhary, Hawley Pruitt, Yi-Han Cheng, George Thom, Michael Newton, Cheyne Kurokawa, Johnathan Guest, Phillip Swanson, Yueh-Ming Loo, Joseph R. Francica, Wade Blair, Mark Esser   +28 more
doaj   +1 more source

The Recent Research Progress of the Tumor mRNA Vaccine

Tumors have long posed a significant threat to human life and health, and the messenger ribonucleic acid (mRNA) vaccine is seen as an attractive approach for cancer immunotherapy due to its developmental simplicity, rapid manufacture, and increased ...
Miying Li, Lidan Hu, Jiaren Zhou, Shaohong Lu, Pan Li, Hao Zhao   +5 more
core   +1 more source

mRNA vaccines as cancer therapies

Chinese Medical Journal
Abstract Cancer remains a major global health challenge, with conventional treatments like chemotherapy and radiotherapy often hindered by significant side effects, lack of specificity, and limited efficacy in advanced cases.
Shaoxiong Huang, Haiying Que, Manni Wang, Xiawei Wei, Yanjie Yin   +4 more
openaire   +3 more sources

Freeze-Drying of mRNA-LNPs Vaccines: A Review

The instability of mRNA vaccines presents significant challenges for their storage, transportation, and large-scale distribution, particularly in resource-limited countries.
Ayyappasamy Sudalaiyadum Perumal, MD Faizul Hussain Khan, Floriane Baudin, Amine A. Kamen   +3 more
core   +1 more source

Responses to Common Misconceptions Relating to COVID-19 Variant-Adapted mRNA Vaccines

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the waning of immunity over time has necessitated the use of booster doses of original coronavirus disease 2019 (COVID-19) vaccines.
Ivan Aloysius, Shanti Pather, Pauline MacDonald, George Kassianos   +3 more
core   +1 more source

Codon pair bias and viral vaccine design

, 2015
The authors acknowledge the long term support of the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.Live attenuated vaccines (LAVs) have prevented morbidity and mortality against a number of important viral diseases (such ...
Tulloch, Fiona Ashley, Ryan, Martin Denis, Pathania, Uday Singh, Luke, Garry Alec   +3 more
core   +1 more source