Results 81 to 90 of about 110,071 (192)
Understanding mRNA COVID-19 vaccines [PDF]
Updated July 15, 2022What You Need to Know\u2022 Messenger RNA (mRNA) vaccines teach our cells how to make a protein that will trigger an immune response inside our bodies.\u2022 Researchers have been studying and working with mRNA vaccines for decades ...
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Background: Rabies is a preventable zoonotic disease caused by the rabies virus (RABV) with a high mortality rate. Most vaccines on the market or under development have issues, such as low single-dose neutralization titer, complex processes, and high ...
Qin Li +4 more
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DNA Vaccines: Their Formulations, Engineering and Delivery
The concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent many diseases ...
Jiafen Hu, Michael Kozak
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Considerations for mRNA Product Development, Regulation and Deployment Across the Lifecycle
With the successful deployment of several mRNA vaccines against SARS-CoV-2, an mRNA vaccine against RSV (respiratory syncytial virus) and a large pipeline of mRNA products against other infectious diseases, cancers and rare diseases, it is important to ...
John H Skerritt
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COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events
, 2023 Each injection of any known vaccine results in a strong expression of pro-inflammatory cytokines. This is the result of the innate immune system activation, without which no adaptive response to the injection of vaccines is possible.
Girolamo Giannotta +2 more
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Frontiers in ImmunologyIntroductionNeedle-free injection system (NFIS) is easy to operate and can decrease needle phobia. Besides, NFIS can increase the interaction of antigens in a more dispersed manner with immune cell at local injection site, which may improve the immune ...
Cenrong Wang +16 more
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The Platform Technology Approach to mRNA Product Development and Regulation
mRNA-lipid nanoparticle (LNP) medicinal products can be considered a platform technology because the development process is similar for different diseases and conditions, with similar noncoding mRNA sequences and lipid nanoparticles and essentially ...
Terry Nolan +3 more
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Background. The combined or multivalent vaccines are actively used in pediatric practice and offer a series of advantages, including a reduced number of injections and visits to the doctor, simplicity of the vaccination schedule and minimization of side ...
Denis A. Kleymenov +14 more
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Increased total plasma TGF-β1 levels and deregulated IgA-IgM axis in chronic obstructive pulmonary disease [PDF]
Journal of Medical BiochemistryBackground: Chronic obstructive pulmonary disease (COPD) is characterised by obstruction of the small airways and includes "flare-ups", which are sudden and significant worsening of symptoms, sometimes caused by infections. Methods: Patients with COPD (n
Minić Rajna +6 more
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A Single-Chain Mpox mRNA Vaccine Elicits Protective Immune Response in Mice
Background: The re-emerging mpox virus (MPXV) has spread to numerous countries and raised global concern. There is an urgent need for a safe and effective mRNA vaccine candidate against MPXV infection.
Hai-Tao Liu +10 more
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