Results 61 to 70 of about 42,200 (256)
Journal of Applied Oral Science, 2013 OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.
Camila Santos Pereira +7 more
doaj +1 more source
MutS‐Homolog2 silencing generates tetraploid meiocytes in tomato (Solanum lycopersicum)
Plant Direct, 2018 MSH2 is the core protein of MutS‐homolog family involved in recognition and repair of the errors in the DNA. While other members of MutS‐homolog family reportedly regulate mitochondrial stability, meiosis, and fertility, MSH2 is believed to participate ...
Supriya Sarma +5 more
doaj +1 more source
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination. [PDF]
PLoS ONE, 2013 Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the post-transcriptional level of ...
Fernando Grigera +2 more
doaj +1 more source
The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair. [PDF]
, 2018 DNA mismatch repair (MMR) corrects mispaired DNA bases and small insertion/deletion loops generated by DNA replication errors. After binding a mispair, the eukaryotic mispair recognition complex Msh2-Msh6 binds ATP in both of its nucleotide-binding sites,
Graham, William J +2 more
core
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. [PDF]
, 2016 Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known.
Bell, Sara N +10 more
core +2 more sources
Pancreatic Cancer and a Novel MSH2 Germline Alteration [PDF]
Pancreas, 2011 The objective of this study was to describe a novel MSH2 missense alteration cosegregating with pancreatic cancer.The method used was an observational study of a kindred in which a novel MSH2 missense alteration was identified.We report a family in which a MSH2 P349L missense alteration is cosegregating with pancreatic cancers among 3 nonsmoking first ...
Lindor, Noralane M. +5 more
openaire +3 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Hereditary Cancer in Clinical Practice, 2019 Background Pathogenic germline variants in MLH1, MSH2 and MSH6 genes account for the majority of Lynch syndrome (LS). In this first report from Pakistan, we investigated the prevalence of pathogenic MLH1/MSH2/MSH6 variants in colorectal cancer (CRC ...
Muhammad Usman Rashid +6 more
doaj +1 more source
Frontiers in Medicine, 2020 Mixed serous-endometrioid endometrial carcinoma is a type of endometrial cancer with relatively low incidence. The genetic factors contributing to the tumorigenesis of mixed carcinoma remains to be explored.
Hong Zheng +4 more
doaj +1 more source