Results 1 to 10 of about 11,769 (169)

Expression of melatonin receptors in trigeminal and sphenopalatine ganglia: potential targets for primary headache disorders [PDF]

The Journal of Headache and Pain
Background Primary headache disorders such as migraine and cluster headache exhibit circadian and circannual variations in attack onset. Melatonin plays a central role in regulating biological rhythms and likely influences the timing of headache attacks.
Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson, Diana N. Krause   +3 more
doaj   +2 more sources

Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study [PDF]

Journal of Medical Biochemistry
Background: Matriptase-2 (MT2) is implicated in iron metabolism, obesity, insulin resistance, and glucose homeostasis. Neurokinin B (NKB) plays a crucial role in gonadotropin secretion, which is essential for reproduction.
Bulut Arikan Funda, Sagsoz Nevin
doaj   +2 more sources

Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish

European Journal of Cell Biology, 2022
The essential trace element zinc is involved in multiple biological processes including development and metabolism, while its role in melanocyte formation is still unclear. Slc30a1a and Slc30a1b are zinc exporters in zebrafish.
Zhidan Xia, Xiu Yang, Xinying Bi, Xiujuan Tong, Junxia Min, Fudi Wang   +5 more
doaj   +1 more source

DNA Methylation and Detoxification in the Earthworm Lumbricus terrestris Exposed to Cadmium and the DNA Demethylation Agent 5-aza-2′-deoxycytidine

Toxics, 2022
Earthworms are well-established model organisms for testing the effects of heavy metal pollution. How DNA methylation affects cadmium (Cd) detoxification processes such as the expression of metallothionein 2 (MT2), however, is largely unknown.
Gerhard P. Aigner, Pamela Nenning, Birgit Fiechtner, Maja Šrut, Martina Höckner   +4 more
doaj   +1 more source

Impaired Expression of Membrane Type-2 and Type-3 Matrix Metalloproteinases in Endometriosis but Not in Adenomyosis

Diagnostics, 2022
Matrix metalloproteinases (MMPs) play an important role in menstruation and endometriosis; however, the membrane-type matrix metalloproteinases (MT-MMPs) are not well studied in endometriosis and adenomyosis.
Jane B. Maoga, Muhammad A. Riaz, Agnes N. Mwaura, Georgios Scheiner-Bobis, Ezekiel Mecha, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad   +7 more
doaj   +1 more source

Structural basis of the ligand binding and signaling mechanism of melatonin receptors

Nature Communications, 2022
Melatonin receptors (MT1 and MT2) are the targets for melatonin, the major neurohormone involved in circadian rhythm and sleep regulation. Here the authors describe the structures of 2-iodomelatonin and ramelteon bound MT1–Gi and MT2-Gi, revealing that ...
Qinggong Wang, Qiuyuan Lu, Qiong Guo, Maikun Teng, Qingguo Gong, Xu Li, Yang Du, Zheng Liu, Yuyong Tao   +8 more
doaj   +1 more source

Short-Term Effects of Spent Mushroom Substrate Mulching Thickness on the Soil Environment, Weed Suppression, Leaf Nutrients, and Nut Characteristics in a Hazelnut Orchard

Agronomy, 2021
Worldwide, a huge amount of solid fermented waste is produced every year during mushroom production. The rational utilization of spent mushroom substrate (SMS) is conducive to environmental protection and the sustainable development of agriculture.
Zhong Ma, Yun-Qi Zhang, Lu-Jun Wang, Guang-Long Hu, Xiao-Qiang Gong, Qian Bai, Shu-Chai Su, Jian-Xun Qi   +7 more
doaj   +1 more source

Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands. [PDF]

PLoS ONE, 2014
A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated.
Yueqing Hu, King H Chan, Xixin He, Maurice K C Ho, Yung H Wong   +4 more
doaj   +1 more source

Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration [PDF]

PeerJ, 2021
Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia.
Shujuan Wang, Wenju Liu, Aiyou Wen, Bing Yang, Xunsheng Pang   +4 more
doaj   +2 more sources

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

Frontiers in Physiology, 2020
BackgroundMelatonin modulates circadian rhythms in physiology and sleep initiation. Genetic variants of the MTNR1B locus, encoding the melatonin MT2 receptor, have been associated with increased type 2 diabetes (T2D) risk. Carriers of the common intronic
Akram Imam, Eva C. Winnebeck, Nina Buchholz, Philippe Froguel, Philippe Froguel, Amélie Bonnefond, Amélie Bonnefond, Michele Solimena, Anna Ivanova, Michel Bouvier, Bianca Plouffe, Bianca Plouffe, Guillaume Charpentier, Angeliki Karamitri, Ralf Jockers, Till Roenneberg, Céline Vetter, Céline Vetter   +17 more
doaj   +1 more source