Results 21 to 30 of about 11,769 (169)

RESULTS OF DYNAMIC ASSESSMENT OF MELATONIN RECEPTOR EXPRESSION IN LYMPHOCYTES IN PATIENTS WITH ACUTE MILD AND SEVERE PANCREATITIS

Вестник хирургии имени И.И. Грекова, 2018
The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers. A correlated analysis was made between obtained results of
D. Yu. Semyonov, Z. H. Osmanov, A. G. Tonoyan, L. G. Shapkina, A. V. Sokolov, M. V. Gorchakova   +5 more
doaj   +1 more source

Prediction of complications of chronic duodenal ulcer using the method of determining the ratio of the level of melatonin receptors in the mucosa

Вестник хирургии имени И.И. Грекова, 2020
Treatment of complications of peptic ulcer disease is an urgent problem in abdominal surgery due to the high prevalence of bleeding (19-57) and perforations (3-14 cases per 100,000 population).The objective of the study was to assess the possibility of ...
Z. Kh. Osmanov, D. Yu. Semenov, A. P. Bogdanov, L. E. Koloscova, A. V. Sokolov, V. B. Vasilyev   +5 more
doaj   +1 more source

Wolbachia elevates host methyltransferase expression to block an RNA virus early during infection. [PDF]

PLoS Pathogens, 2017
Wolbachia pipientis is an intracellular endosymbiont known to confer host resistance against RNA viruses in insects. However, the causal mechanism underlying this antiviral defense remains poorly understood.
Tamanash Bhattacharya, Irene L G Newton, Richard W Hardy   +2 more
doaj   +1 more source

The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors

Scientific Reports, 2022
Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
doaj   +1 more source

Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism

Reproductive Biology and Endocrinology, 2019
Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep
Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan, Xingxu Zhao   +8 more
doaj   +1 more source

Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. [PDF]

PLoS ONE, 2015
The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans.
Fanny Söderquist, Per M Hellström, Janet L Cunningham   +2 more
doaj   +1 more source

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Cells, 2022
There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao   +17 more
doaj   +1 more source

Novel Conformationally Constrained Analogues of Agomelatine as New Melatoninergic Ligands

Molecules, 2012
Novel conformationally restricted analogues of agomelatine were synthesized and pharmacologically evaluated at MT1 and MT2 melatoninergic receptors. Replacement of the N-acetyl side chain of agomelatine by oxathiadiazole-2-oxide (compound 3), oxadiazole ...
Marouan Rami, Elodie Landagaray, Mohamed Ettaoussi, Koussayla Boukhalfa, Daniel-Henri Caignard, Philippe Delagrange, Pascal Berthelot, Saïd Yous   +7 more
doaj   +1 more source

Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi, Mohammad khaksari, Gholamreza Asadikaram, Zahra soltani, Nava Shahrokhi   +4 more
doaj   +1 more source

Cu(I) binds to Zn7-MT2 via two parallel pathways

Metallomics, 2023
Abstract Metallothionein proteins are essential for Cu(I) and Zn(II) homeostasis as well as heavy metal detoxification. The metallation properties of MT2 are of great interest due to their wide patterns of expression and correlation with multiple diseases including cancers, neurological disorders, and respiratory diseases.
Adyn Melenbacher, Martin J Stillman
openaire   +2 more sources