Results 41 to 50 of about 11,769 (169)
Cell Proliferation, EarlyView.Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo +6 more
wiley +1 more source
Frontiers in Microbiology, 2016 The need for finding fungicides against Fusarium is a key step in the chemical plant protection and using appropriate chemical agents. Existing, conventional methods of evaluation of Fusarium isolates resistance to fungicides are costly, time-consuming ...
Magdalena eFrąc +3 more
doaj +1 more source
Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes [PDF]
Endocrinology, 2001 Several reports have demonstrated that the pineal hormone, melatonin, plays an important role in body mass regulation in mammals. To date, however, the target tissues and relevant biochemical mechanisms involved remain uncharacterized. As adipose tissue is the principal site of energy storage in the body, we investigated whether melatonin could also ...
L, Brydon +4 more
openaire +2 more sources
Descriptive epidemiology of long‐term injuries in jump racing Thoroughbreds in Great Britain
Equine Veterinary Journal, EarlyView.Abstract Background Race‐related injuries in horse racing, especially those requiring extended recovery, are a welfare concern and threaten the sport's social licence. Previous studies predominantly report on fatalities; however, serious non‐fatal musculoskeletal injuries often end horses' racing careers or have a high recurrence risk.
Sophia McDonald +3 more
wiley +1 more source
Safety of intraocular anti-VEGF antibody treatment under in vitro HTLV-1 infection
Frontiers in Immunology, 2023 IntroductionHTLV-1 (human T-cell lymphotropic virus type 1) is a retrovirus that infects approximately 20 million people worldwide. Many diseases are caused by this virus, including HTLV-1–associated myelopathy, adult T-cell leukemia, and HTLV-1 uveitis.
Yuan Zong +5 more
doaj +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Frontiers in Physiology, 2022 The melatoninergic system comprises the neurohormone melatonin and its molecular targets. The major source of melatonin is the pineal organ where melatonin is rhythmically produced during darkness.
Martina Pfeffer +3 more
doaj +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]
PLoS ONE, 2018 Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier +8 more
doaj +1 more source
Resilient IT: Winning With People and Process
Information Systems Journal, EarlyView.ABSTRACT In today's dynamic environment, IT organisations face numerous challenges from disruptions such as natural disasters, cybersecurity threats, international conflicts, evolving regulations, pandemics and recent global incidents such as the CrowdStrike outage.
Wesam Helou +2 more
wiley +1 more source