Results 51 to 60 of about 11,769 (169)

MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]

Journal of Pineal Research, 2019
AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul, Lapmanee, Sarawut, Schuster, Carole, Guardiola, Béatrice, Hicks, David, Pevet, Paul, Felder‐schmittbuhl, Marie Paule   +6 more
openaire   +3 more sources

Validation of clinically related aging models based on enamel wear

Journal of Prosthodontics, EarlyView.
Abstract Purpose Physiological and erosive wear reported in clinical studies were reviewed, and in vitro aging models were developed to simulate and compare the effect of aging on human teeth with the review data obtained from clinical studies. Methods A review of clinical studies and randomized clinical trials that quantify enamel wear was performed ...
Beshr Hajhamid, Laurent Bozec, Hassan Moghadam, Howard Tenenbaum, Grace M. De Souza, Eszter Somogyi‐Ganss   +5 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou, Ioannis Anastasiou, Panagiota Fallon, Eleni Glarou, Nikolaos Christodoulou, Andreas S. Lappas, Vasilios‐Panteleimon Bozikas, Myrto T. Samara   +7 more
wiley   +1 more source

Escape Body: A Gamified Problem‐Based Learning Project in Primary Education

School Science and Mathematics, EarlyView.
ABSTRACT Young learners' lack of motivation to study scientific‐related subjects nowadays is a topic of concern in our society. This study followed a quasi‐experimental design with a predominantly quantitative methods approach, complemented by qualitative data, to investigate how the combination of gamified and problem‐based learning could influence ...
Sergio Tirado‐Olivares, Maria Navío‐Inglés, Javier del Olmo‐Muñoz, Rosa M. Toledano   +3 more
wiley   +1 more source

MT2-MMP induces proteolysis and leads to EMT in carcinomas

Oncotarget, 2016
Epithelial-mesenchymal transition (EMT) is critical for carcinoma invasiveness and metastasis. To investigate the role of membrane-type-2 matrix metalloproteinase (MT2-MMP) in EMT, we generated lentiviral constructs of wild-type (WT) and an inactive Glu260Ala (E260A) mutant MT2-MMP and derived stably transfected HCT116 and A549 cell lines.
Liu, Yusi, Sun, Xiaojiao, Feng, Jinfa, Deng, Li-Li, Liu, Yihao, Li, Bokang, Zhu, Mingyue, Lu, Changlian, Zhou, Lingyun   +8 more
openaire   +3 more sources

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, EarlyView.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source

Superpartner mass measurements with 1D decomposed MT2

, 2009
We propose a new model-independent technique for mass measurements in missing energy events at hadron colliders. We illustrate our method with the most challenging case of a short, single-step decay chain. We consider inclusive same-sign chargino pair production in supersymmetry, followed by leptonic decays to sneutrinos.
Konar, Partha, Kong, Kyoungchul, Matchev, Konstantin T., Park, Myeonghun   +3 more
openaire   +2 more sources

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, Volume 59, Issue 4, Page 590-613, April 2026.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Identification of Metallothionein Gene in Human Plasma: A Molecular Analysis of Cadmium and Lead Pollution in Gas Station Environment

Jurnal Pendidikan IPA Indonesia, 2018
Metallothionein (MTs) is a protein that binds to metals, cysteine-rich and has low molecular weights. Metallothionein binds metals and has some essential cellular functions, such as transportation, storage, and metal detoxification.
N. K. Dewi, A. Yuniastuti, A. M. A. Ahmed   +2 more
doaj   +1 more source