Results 201 to 210 of about 400,251 (340)

Involvement of the Akt/mTOR pathway on EGF‐induced cell transformation [PDF]

, 2003
Masaaki Nomura, Zhiwei He, Ichiko Koyama, Weiya Ma, Ken–ichi Miyamoto, Zigang Dong   +5 more
openalex   +1 more source

Targeting mTOR: up-to-date mTOR inhibitors

Biorganic and Medicinal Chemistry Reports, 2019
Banu Kilic, Seyhan Sahan Firat, Meryem Temiz-Resitoglu   +2 more
openaire   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Ca²⁺‐ and phospholipase D‐dependent and ‐independent pathways activate mTOR signaling [PDF]

, 2003
Lisa M. Ballou, Ya-Ping Jiang, Guangwei Du, Michael A. Frohman, Richard Z. Lin   +4 more
openalex   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Targeting the mTOR Signaling Pathway Through miR-100 and miR-101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention. [PDF]

Cancer Rep (Hoboken)
Kargar M, Allahbakhshian Farsani M, Garavand J, Gorji M, Rafiee M, Bahreiny SS, Mohammadi MH.   +6 more
europepmc   +1 more source

Identification of a Conserved Motif Required for mTOR Signaling

, 2002
Stefanie S. Schalm, John Blenis
openalex   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

The dual role of mTOR signaling in lung development and adult lung diseases. [PDF]

Cell Biosci
Bao J, Bao W, Song Y, Li Z, Kan L, Fu J, Zhang D.   +6 more
europepmc   +1 more source

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

, 2003
Andrew R. Tee, Brendan D. Manning, Philippe P. Roux, Lewis C. Cantley, John Blenis   +4 more
openalex   +1 more source