Results 201 to 210 of about 266,976 (313)

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling. [PDF]

PLoS Genet
Botero V, Barrios J, Knauss A, Dahlen G, Rosendahl E, Colodner KJ, Tomchik SM.   +6 more
europepmc   +1 more source

Integrated proteasomal and lysosomal activity shape mTOR-regulated proteome remodeling

Danica S. Cui, Samantha M. Webster, Joseph H. Davis   +2 more
openalex   +1 more source

Mechanism of action of quercetin in regulating cellular autophagy in multiple organs of Goto-Kakizaki rats through the PI3K/Akt/mTOR pathway [PDF]

Zhiqun Guo, Jingyu Zhang, M. Li, Zengwei Xing, Xi Li, Jiaqi Qing, Yuan Zhang, Lemei Zhu, Mingxu Qi, Xuemin Zou   +9 more
openalex   +1 more source

mTOR in cerebrovascular disease

Aging, 2019
Van Skike, Candice E., Galvan, Veronica
openaire   +2 more sources

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

Correction to "mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression". [PDF]

Mediators Inflamm
europepmc   +1 more source

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner. [PDF]

Sci Rep
Lacouture A, Sylla MS, Germain L, Fréville L, Lafront C, Weidmann C, Jobin C, Laplante M, Huot MÉ, Lambert JP, Audet-Walsh É.   +10 more
europepmc   +1 more source

Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways [PDF]

Delu Zheng, Chenli Cui, Chengsong Ye, Chen Shao, Xiujing Zha, Ying Xu, Xu Liu, Can Wang   +7 more
openalex   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Macropinocytosis and Vascularization Determine Response to mTOR Inhibitors in Lung Squamous Cell Carcinoma. [PDF]

Cancer Res
Brady MR, Matulionis N, Christofk HR, Garon EB, Lisberg A, Shackelford DB, Momcilovic M.   +6 more
europepmc   +1 more source