Results 251 to 260 of about 427,120 (360)

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Oenothera Biennis Water Extract Inhibits the Nlrp3 Inflammasome by Activating Microglial Autophagy Via the Ampk-Pi3k/Akt/Mtor Pathway in Alzheimer's Disease

Li Zhang, Lan Deng, Jing Wei, Xiaogang Zhou, Dongsheng Fan, Jianming Wu, Feng Chi, Nan Jiang, Dalian Qin, Fang Ren, Yu Lu, Anguo Wu   +11 more
openalex   +1 more source

Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation

, 2015
Xiaodong Ma, Xiaoqing Lv, Ni Qiu, Bo Yang, Qiaojun He, Yongzhou Hu   +5 more
openalex   +1 more source

SWOG S0722: Phase II Study of mTOR Inhibitor Everolimus (RAD001) in Advanced Malignant Pleural Mesothelioma (MPM) [PDF]

, 2015
Sai‐Hong Ignatius Ou, James Moon, Linda L. Garland, Philip C. Mack, Joseph R. Testa, Anne S. Tsao, A. J. Wozniak, David R. Gandara   +7 more
openalex   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Upregulated miR-204-5p inhibits oral squamous cell carcinoma progression via inducing autophagy-promoted apoptosis by targeting PIK3CB. [PDF]

Sci Rep
Chen C, Gou Q, Jin W, Liao M, Li Z, Xie Q, Huang H.   +6 more
europepmc   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Dietary arginine modulates egg production and mTOR signalling pathway gene expression in adult Japanese quail (<i>Coturnix japonica</i>). [PDF]

Vet Anim Sci
Gashew M, Reda GK, Almira FN, Abdelbary EM, Gulyás G, Knop R, Csernus B, Szabó C, Lendvai ÁZ, Czeglédi L.   +9 more
europepmc   +1 more source

mTOR in cerebrovascular disease

Aging, 2019
Van Skike, Candice E., Galvan, Veronica
openaire   +2 more sources