Results 281 to 290 of about 266,976 (313)

[mTOR inhibitors].

Nihon rinsho. Japanese journal of clinical medicine, 2010
Mammalian target of rapamycin (mTOR) protein complex functions as an integration center for various intracellular signaling pathways involving proliferation, cell survival, and angiogenesis. These pathways are frequently abnormally regulated in cancer.
openaire   +1 more source

mTOR

2012
openaire   +2 more sources

mTOR

2007
John B. Easton, Peter J. Houghton
openaire   +1 more source

[mTOR inhibitor].

Gan to kagaku ryoho. Cancer & chemotherapy, 2011
Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
openaire   +1 more source

Recent Progress in the Management of Advanced Renal Cell Carcinoma

Ca-A Cancer Journal for Clinicians, 2007
Brian I Rini
exaly  

mTOR: from growth signal integration to cancer, diabetes and ageing

Nature Reviews Molecular Cell Biology, 2010
Roberto Zoncu, Alejo Efeyan, David M Sabatini   +2 more
exaly  

Rapamycin passes the torch: a new generation of mTOR inhibitors

Nature Reviews Drug Discovery, 2011
Michael N Hall
exaly  

Current development of mTOR inhibitors as anticancer agents

Nature Reviews Drug Discovery, 2006
Guido Kroemer
exaly  

MTOR

2011
openaire   +1 more source

mTOR signalling and cellular metabolism are mutual determinants in cancer

Nature Reviews Cancer, 2018
Michael N Hall
exaly