Results 61 to 70 of about 400,251 (340)

Roles of mTOR and p-mTOR in Gastrointestinal Stromal Tumors

Asian Pacific Journal of Cancer Prevention, 2013
This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors.Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p ...
Hui Chuan Zhao, Hong Yu Zhu, Xiao Yan Wang, Lan Ying Zou, Jun Chuan Li, Ting Xuan Chen, Jun Xu   +6 more
openaire   +4 more sources

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor [PDF]

Nature, 2016
Precision medicines exert selective pressure on tumour cells that leads to the preferential growth of resistant subpopulations, necessitating the development of next-generation therapies to treat the evolving cancer. The PIK3CA-AKT-mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small ...
Zhan Yao, Sabina Cosulich, Masanori Okaniwa, Vanessa Rodrik-Outmezguine, Teresa Klinowska, Kevan M. Shokat, Kevan M. Shokat, Derek Barratt, Arpitha Banaji, Helen Won, Neal Rosen, Claire McWhirter, M.F. Berger, Elisa de Stanchina, Wai Wong, Chris J. Novotny   +15 more
openaire   +3 more sources

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]

, 2019
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis, De Prijck, Sofie, Deswarte, Kim, Fayazpour, Farzaneh, Janssens, Sophie, Lambrecht, Bart, Martens, Arne, Takahashi, Nozomi, Tavernier, Simon, van Helden, Mary, van Loo, Geert, Van Moorleghem, Justine, Vandenabeele, Peter, Vanheerswynghels, Manon, Vergote, Karl, Vetters, Jessica, Vivier, Eric, Wahlen, Sigrid   +17 more
core   +4 more sources

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Orphanet Journal of Rare Diseases
Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates key cellular processes including cell growth, autophagy and metabolism.
Laura Mantoan Ritter, Nicholas M. P. Annear, Emma L. Baple, Leila Y. Ben-Chaabane, Istvan Bodi, Lauren Brosson, Jill E. Cadwgan, Bryn Coslett, Andrew H. Crosby, D. Mark Davies, Nicola Daykin, Stefanie Dedeurwaerdere, Christina Dühring Fenger, Elaine A. Dunlop, Frances V. Elmslie, Marie Girodengo, Sophie Hambleton, Anna C. Jansen, Simon R. Johnson, Kelly C. Kearley, John C. Kingswood, Liisi Laaniste, Katherine Lachlan, Andrew Latchford, Ralitsa R. Madsen, Sahar Mansour, Simeon R. Mihaylov, Louwai Muhammed, Claire Oliver, Tom Pepper, Lettie E. Rawlins, Ina Schim van der Loeff, Ata Siddiqui, Pooja Takhar, Katrina Tatton-Brown, Andrew R. Tee, Priyanka Tibarewal, Charlotte Tye, Sila K. Ultanir, Bart Vanhaesebroeck, Benjamin Zare, Deb K. Pal, Joseph M. Bateman   +42 more
doaj   +1 more source

mTOR signaling in tumorigenesis [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation. Deregulation of the mTOR signaling pathway is one of the most commonly observed pathological alterations in human cancers.
Wenyi Wei, Kai Xu, Pengda Liu
openaire   +3 more sources

Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund.Emerging data suggest that nutritional status and body weight are related to reproductive function, and nutrient imbalances during pregnancy lead to changes in the ...
Foster, H, Goumenou, A, Harvey, AJ, Kara, A, Karteris, E, Mparmpakas, D, Zachariades, E   +6 more
core   +2 more sources

Aerosolizable marine phycotoxins and human health effects : in vitro support for the biogenics hypothesis [PDF]

, 2020
Respiratory exposure to marine phycotoxins is of increasing concern. Inhalation of sea spray aerosols (SSAs), during harmful Karenia brevis and Ostreopsis ovata blooms induces respiratory distress among others. The biogenics hypothesis, however, suggests
Asselman, Jana, Beck, Ilse, De Rijcke, Maarten, De Schamphelaere, Karel, Huysman, Steve, Janssen, Colin, Van Acker, Emmanuel, Vanhaecke, Lynn   +7 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

mTOR, autophagy, and reprogramming

Frontiers in Cell and Developmental Biology, 2014
Nuclear reprogramming to achieve induced-pluripotency by the Yamanaka factors (Takahashi and Yamanaka, 2006) is largely viewed as a consequence of a cascade of expression profile changes, along with alterations in epigenetic markings, which are primarily nuclear events.
openaire   +5 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source