Results 71 to 80 of about 427,120 (360)

AMP-activated Protein Kinase Activation Suppresses Protein Synthesis and mTORC1 Signaling in Chick Myotube Cultures

The Journal of Poultry Science, 2022
Protein synthesis in skeletal muscle is considered one of the most energy-consuming cellular processes. AMP-activated protein kinase (AMPK) is a metabolic master switch that regulates glucose and lipid metabolism, and it is implicated in protein ...
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Dissecting the role of mTOR: Lessons from mTOR inhibitors

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
Recent years have observed significant advances in our understanding of how the serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as cell survival, growth and proliferation. Consistent with its role in cell proliferation, the mTOR pathway is frequently hyperactivated in a number of human malignancies and is thus ...
Dowling, Ryan J.O., Topisirovic, Ivan, Fonseca, Bruno D., Sonenberg, Nahum   +3 more
openaire   +2 more sources

Mechanistic target of rapamycin (mTOR) activation during ruminant mammary development and function : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand [PDF]

, 2013
This thesis examines the abundance of total and activated mechanistic target of rapamycin (mTOR) pathway components in the developing and functional ruminant mammary gland. mTOR pathway activation is stimulated by a wide range of intra- and extracellular
Sciascia, Quentin Leon
core  

PPAR gamma/mTOR signalling: striking the right balance in cartilage homeostasis [PDF]

, 2015
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work ...
Afif, Betz, Boileau, Caramés, Chen, Damyanovich, Francesco Dell'Accio, Glasson, Jacinto, Joanna Sherwood, Johnson, Kim, Laplante, Miller, Reginster, Saito, Sampson, Sarbassov, Sherwood, Vasheghani, Vasheghani, Yang, Yin, Zhang   +23 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Combined physical activity in the prevention of cardiovascular diseases: from physiological to molecular adaptation mechanisms

Клиническая практика
Physical activity is recognized as the most important non-medicinal tool for the prevention of cardiovascular diseases, however, the highest efficiency is demonstrated by the programs combining various types of physical load.
Abduragim R. Magomedov, Polina V. Rykova, Bogdan A. Anokhin, Arthur Kh. Melikian, Minas A. Agaronyan, Arina G. Sarkisyan, Ekaterina S. Shimko, Ayshat Yu. Yusupova, Elvina R. Irgalieva, Eset M. Bokova, Rashid S. Mokaev, Darya V. Leonova, Adil Sh. Kendzhametov   +12 more
doaj   +1 more source

Elucidating the role of Lkb1 and mTOR in adipose tissue

Adipocyte, 2019
Adipose tissues, function as energy metabolism and endocrine organ, are closely associated with metabolic diseases such as obesity, insulin resistance and diabetes.
Ziye Xu, Wenjing You, Fengqin Wang, Yizhen Wang, Tizhong Shan   +4 more
doaj   +1 more source

Double agent mTOR [PDF]

Epilepsy Currents, 2019
[Box: see text]
openaire   +2 more sources