Results 131 to 140 of about 108,192 (330)

Codependencies of mTORC1 signaling and endolysosomal actin structures [PDF]

, 2023
Amulya Priya, Sandra Antoine‐Bally, Anne‐Sophie Macé, Pedro Monteiro, Valentin Sabatet, David Remy, Florent Dingli, Damarys Loew, Constantinos Demetriades, Alexis Gautreau, Philippe Chavrier   +10 more
openalex   +1 more source

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Pathogenic hyperactivation of mTORC1 by cytoplasmic EP300 in Hutchinson-Gilford progeria syndrome

Cell Stress
In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability.
Lucille Ferret, Guido Kroemer, Mojgan Djavaheri-Mergny   +2 more
doaj   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Guidelines for the Anti‐Obesity Assays of Food Bioactives in Caenorhabditis elegans

AgriFood: Journal of Agricultural Products for Food, EarlyView.
This Guideline uses Caenorhabditis elegans as a model organism to systematically explain and summarize the research strategies and experimental methods for the anti‐obesity effects of food bioactives. ABSTRACT The obesity has become a global public health problem and is closely related to a variety of chronic diseases.
Rui Lu
wiley   +1 more source

mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

eLife, 2019
The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in dendritic translation and in learning and memory. We previously showed that heavy alcohol use activates mTORC1 in the orbitofrontal cortex (OFC) of rodents (Laguesse et al.,
Nadege Morisot, Khanhky Phamluong, Yann Ehinger, Anthony L Berger, Jeffrey J Moffat, Dorit Ron   +5 more
doaj   +1 more source

p53 Strikes mTORC1 by Employing Sestrins [PDF]

Cell Metabolism, 2008
The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.
openaire   +2 more sources