Results 131 to 140 of about 75,068 (344)
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner [PDF]
, 2006 Jennifer Skeen +8 more
openalex +1 more source
The Emerging Roles of mTORC1 in Macromanaging Autophagy
Cancers, 2019 Autophagy is a process of self-degradation that enables the cell to survive when faced with starvation or stressful conditions. The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin, plays a critical role in ...
Akpedje S. Dossou, A. Basu
semanticscholar +1 more source
Advanced Science, EarlyView.Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin +6 more
wiley +1 more source
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
eLife, 2019 The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in dendritic translation and in learning and memory. We previously showed that heavy alcohol use activates mTORC1 in the orbitofrontal cortex (OFC) of rodents (Laguesse et al.,
Nadege Morisot +5 more
doaj +1 more source
mTORC1 Signaling Can Regulate Growth Factor Activation of p44/42 Mitogen-activated Protein Kinases through Protein Phosphatase 2A [PDF]
, 2007 Franklin C. Harwood +2 more
openalex +1 more source
Autophagy, 2019 A switch from autophagy to apoptosis is implicated in chondrocytes during the osteoarthritis (OA) progression with currently unknown mechanism(s). In this study we utilized a flow fluid shear stress (FFSS) model in cultured chondrocytes and a unilateral ...
Hongxu Yang +10 more
semanticscholar +1 more source
mTORC1 and mTORC2 in Energy Homeostasis
, 2010 Publisher Summary This chapter discusses the role of mammalian target of rapamycin complex 1 (mTORC1) and mammalian target of rapamycin complex 2 (mTORC2) in energy homeostasis. Energy homeostasis is the regulation of energy uptake, storage, and expenditure such that an organism maintains a balanced metabolic state.
Cornu, M., Hall, M. N.
openaire +3 more sources
Advanced Science, EarlyView.Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen +9 more
wiley +1 more source
Communicative & Integrative Biology, 2018 During nerve development, Schwann cells (SCs) build multilayered myelin sheaths around axons to accelerate nerve conduction. The mechanistic target of rapamycin complex 1 (mTORC1) downstream of PI3K/AKT signaling lately emerged as a central anabolic ...
Keit Men Wong, Bogdan Beirowski
doaj +1 more source