Results 131 to 140 of about 102,812 (293)

Pathogenic hyperactivation of mTORC1 by cytoplasmic EP300 in Hutchinson-Gilford progeria syndrome

Cell Stress
In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability.
Lucille Ferret, Guido Kroemer, Mojgan Djavaheri-Mergny   +2 more
doaj   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

p53 Strikes mTORC1 by Employing Sestrins [PDF]

Cell Metabolism, 2008
The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.
openaire   +2 more sources

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

RalGAPs Regulate mTORC1 Signaling [PDF]

Cancer Discovery, 2014
Abstract A RalGAP–RalB pathway regulates mTORC1 activity independent of Rheb.
openaire   +1 more source

mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

eLife, 2019
The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in dendritic translation and in learning and memory. We previously showed that heavy alcohol use activates mTORC1 in the orbitofrontal cortex (OFC) of rodents (Laguesse et al.,
Nadege Morisot, Khanhky Phamluong, Yann Ehinger, Anthony L Berger, Jeffrey J Moffat, Dorit Ron   +5 more
doaj   +1 more source

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. [PDF]

, 2020
Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear.
Chen, Ye-Guang, De Pinho, Ronald A, Habib, Samy L, He, Dan, Li, Baojie, Liu, Huijuan, Peng, Peike, Ruan, Xinsen, Ruan, Yuanyuan, Wang, Yibin, Wu, Hongguang, Xiang, Jinnan, Yu, Qiang, Zhang, Hongbing   +13 more
core  

The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]

, 2018
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila, Badiali, Manuela, Besharat, Zein Mersini, Capper, David, Carai, Andrea, Catanzaro, Giuseppina, Chiacchiarini, Martina, Ferretti, Elisabetta, Giangaspero, Felice, Locatelli, Franco, Marras, Carlo Efisio, Mascelli, Samantha, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Raso, Alessandro, Schrimpf, Daniel, Stichel, Damian, Tartaglia, Marco, von Deimling, Andreas   +19 more
core   +1 more source