Results 141 to 150 of about 66,391 (264)

mTORC1 Promotes SARS-CoV-2 Replication and Attenuates Type I Interferon Responses in the Alveolar Epithelium: A Computational and Experimental Study. [PDF]

Bull Math Biol
Kutuva AR, Ribeiro HA, Lima FT, Schaller MA, Mehrad B, Laubenbacher R.   +5 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

The role of mTORC2/RICTOR in immune cells and inflammatory diseases. [PDF]

Inflamm Res
Xu J, Zhong W, Xin F, Xu F, Zheng Z, Guo F.   +5 more
europepmc   +1 more source

Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley   +1 more source

Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1⁺ pathologic fibroblasts. [PDF]

Sci Adv
Wilson JA, Walters R, Contento G, Rossanese M, Guillotin D, Ward AI, Hynds RE, Jamal-Hanjani M, Kaminski N, Parolo S, Platé M, Chambers RC.   +11 more
europepmc   +1 more source

Advancements and prospects in bioinformatics and omics for colorectal cancer: A dual bibliometric analysis of global trends and top cited publications

Journal of Intelligent Medicine, EarlyView.
This dual bibliometric analysis examined 5129 publications and the top 100 most cited publications on bioinformatics and omics in colorectal cancer (2004–2025) from the Web of Science Core Collection. Using SCImago Graphica, VOSviewer, CiteSpace, and R Studio, we analyzed global trends, countries/regions, institutions, journals, authors, references ...
Yue Huang, Ziye Peng, Xiangyu Wang, Likun Yang, Yifei Gao, Ximo Wang, Jiaxin Li, Zhengcun Pei   +7 more
wiley   +1 more source

mTORC1 Activation Links Chronic Stress to Meso-Circuit Desynchronization and Accelerated Amyloid Pathology via Autophagic Dysfunction. [PDF]

CNS Neurosci Ther
Zou Y, Yang J, Li Y, Wang G, Lu W, Chen X, Ma X, Chen K, Liang P, Wu Y, Zhuo T.   +10 more
europepmc   +1 more source

WDR72 Drives Esophageal Squamous Cell Carcinoma Progression by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a high rate of recurrence and metastasis, necessitating the identification of novel therapeutic targets. WD repeat‐containing protein 72 (WDR72) has been linked to various cancers, but its specific biological function and underlying mechanism in ESCC remain largely ...
Hao Wu, Zhong‐Xiang Jiang, Zheng Jiang
wiley   +1 more source

Glycolysis Drives TLR Ligand-Induced Maturation and Immune Activation of Liver Sinusoidal Endothelial Cells. [PDF]

Liver Int
Shu Y, Yan H, Sun H, Gu X, Littwitz-Salomon E, Liu J, Wu J, Yang D, Zheng X, Lu M, Du Y.   +10 more
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source