Results 291 to 300 of about 75,068 (344)

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy. [PDF]

Mol Cancer
Lv Y, Li Z, Liu S, Zhou Z, Song J, Ba Y, Weng S, Zuo A, Xu H, Luo P, Cheng Q, Zhang C, Ning J, Chen Y, Zhang Y, Liu Z, Han X.   +16 more
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Targeting SLC7A5 in lung squamous cell carcinoma: implications for cancer metabolism shift and boron neutron capture therapy resistance. [PDF]

Oncogenesis
Lin YJ, Wu YC, Liu YJ, Yeh WC, Huang YC, Zhang SA, Chen A, Zheng MY, Liu HM, Chou FI, Pan ST, Chou MY, Chou YT.   +12 more
europepmc   +1 more source

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal, EarlyView.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio, Luis A. Baeza, Haiqing Bai, Tommaso Colangelo, Simone Castagnozzi, Marta Marzotto, Maria Concetta Cufaro, Virginia Lotti, Yu‐Chieh Yuan, Matteo Mucci, Longlong Si, Mariachiara Zuccarini, Maria Tredicine, Simona D'Orazio, Damiana Pieragostino, Piero Del Boccio, Claudio Sorio, Marco Trerotola, Mario Romano, Roberto Plebani   +19 more
wiley   +1 more source

Sestrins in Carcinogenesis-The Firefighters That Sometimes Stoke the Fire. [PDF]

Cancers (Basel)
Haidurov A, Budanov AV.
europepmc   +1 more source

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25

The FEBS Journal, EarlyView.
Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found that the small GTPase Rab25 promoted the expression of ADAMTS5 in ovarian cancer cells through the activation of the NF‐κB signalling pathway.
Shengnan Yuan, Rachele Bacchetti, Jamie Adams, Doretta Cuffaro, Armando Rossello, Elisa Nuti, Salvatore Santamaria, Elena Rainero   +7 more
wiley   +1 more source

RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch. [PDF]

J Inflamm (Lond)
Liu Y, Gao S, Li Z, Yin L, Ge S, Zhao Y, Wang H, Wan B, Shao Q.   +8 more
europepmc   +1 more source

Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’

The FEBS Journal, EarlyView.
Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko, Jarosław Poznański, Marzena Sieńko   +2 more
wiley   +1 more source

A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments. [PDF]

J Cell Commun Signal
Liu S, Zhang J.
europepmc   +1 more source