Results 271 to 280 of about 103,930 (303)

MTORC1-dependent reprogramming

Science Signaling, 2020
DDIT4 and IFRD1 trigger the inhibition and reactivation of MTORC1 during regenerative repair.
openaire   +1 more source

Lysosomal cholesterol activates mTORC1

Science, 2017
Cholesterol Sensing The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work has delineated a pathway through which amino acids regulate mTORC1.
openaire   +2 more sources

mTORC1 goes sensorless

Science Signaling, 2019
A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
openaire   +1 more source

mTORC1 signalling and mRNA translation

Biochemical Society Transactions, 2009
Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
openaire   +3 more sources

Chaperoning mTORC1 Activity

Science Signaling, 2010
Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
openaire   +1 more source

Thwarting Dyskinesia by Targeting mTORC1

Science Signaling, 2009
Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with l -DOPA treatment.
openaire   +2 more sources

Lysosomal catch-and-release controls mTORC1

Nature Cell Biology, 2018
Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.
Aaron M, Hosios, Brendan D, Manning
openaire   +2 more sources

mTORC1 Stimulates Glutamine Metabolism

Science Signaling, 2013
The mammalian target of rapamycin complex 1 promotes glutamine metabolism by repressing expression of the gene encoding the sirtuin SIRT4.
openaire   +1 more source

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Nature Reviews Molecular Cell Biology, 2023
Roberta Peruzzo, Roberto Zoncu
exaly  

RAG-ulating mTORC1 with amino acids

Nature Reviews Molecular Cell Biology, 2021
Jenna L Jewell
exaly