Results 251 to 260 of about 103,930 (303)

Stanniocalcin 2‐Induced Autophagy Confers Resistance of Lung Cancer Cells to EGFR Inhibition via the ERK/Beclin 1 Signaling

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are effective in treating NSCLC with EGFR mutations, the development of resistance limits their long‐term efficacy. Autophagy has been implicated as a potential mechanism behind this acquired resistance.
Yi‐Nan Liu, Yi‐Ling Chen, Meng‐Feng Tsai, Shang‐Gin Wu, Tzu‐Hua Chang, Tzu‐Hsiu Tsai, Jin‐Yuan Shih   +6 more
wiley   +1 more source

Multi-omics integration reveals tumor and microenvironmental heterogeneity in malignant pleural mesothelioma. [PDF]

Discov Oncol
Hu H, Li L, Bian W, Wu X.
europepmc   +1 more source

Single‐nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng, Fengjun Zhu, Dezhi Cao, Yang Sun, Lin Li, Zeshi Tan, Cong Li, Xiaofan Ren, Yidi Liu, Zhiqiang Lin, Dongfang Zou   +10 more
wiley   +1 more source

Hyperactivation of mTORC1 blocks stem cell fate transitions through TFE3-NuRD association. [PDF]

EMBO Rep
Li P, Xu S, Wu X, Gao Y, Ahmed T, Huang Y, Qin D, Qin B, Wang L, Xu X.   +9 more
europepmc   +1 more source

STK25 inhibits cancer‐associated fibroblast activation to overcome cetuximab resistance in colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou, Jiangbo Chen, Hao Hao, Tongkun Song, Lin Song, Pu Xing, Kai Weng, Yumeng Ran, Xinying Yang, Xiaowen Qiao, Jie Chen, Ruibin Yao, Hong Yang, Lei Chen, Jiabo Di, Kai Xu, Xiangqian Su, Beihai Jiang   +17 more
wiley   +1 more source

mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR⁺/HER2^- breast cancer. [PDF]

Cell Death Dis
von Wichert L, Stroh A, Witt M, Wanzel M, Mernberger M, Griewing S, Wündisch T, Pfitzner BM, Teply-Szymanski J, Litmeyer AS, Denkert C, Wagner U, Stiewe T, Gremke N.   +13 more
europepmc   +1 more source

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells. [PDF]

J Immunol
Kania AK, Sanin DE, Gu X, Gidley M, Kokosinski E, Smith A, Pearce E, Pearce EJ.   +7 more
europepmc   +1 more source

Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma. [PDF]

Mol Biomed
Park MJ, Lee S, Kim DH, Kim MK, Jang BK, Yoon G, Park M, Jeong GH, Byun JK, Choi YK, Park KG.   +10 more
europepmc   +1 more source

Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activation. [PDF]

Sci Rep
Sato E, Nakamura Y, Fujimoto M, Shimada IS, Iwaki T, Ieda D, Negishi Y, Hattori A, Kato Y, Saitoh S.   +9 more
europepmc   +1 more source

Amino Acid Signaling in Skeletal Muscle Is Blunted by Prematurity in a Piglet Model. [PDF]

J Nutr
Ramos Dos Santos AC, Suryawan A, Jang KB, Parada RD, Mohammad MA, Fiorotto ML, Davis TA.   +6 more
europepmc   +1 more source