Results 241 to 250 of about 63,007 (266)

Lysosomal cholesterol activates mTORC1

Science, 2017
Cholesterol Sensing The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work has delineated a pathway through which amino acids regulate mTORC1.
openaire   +2 more sources

An arginine sensor for mTORC1

Science Signaling, 2016
Binding of arginine to CASTOR1 disrupts its binding to a complex that promotes mTORC1 activity.
openaire   +1 more source

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Cell, 2021
Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester   +2 more
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell, 2021
Charles L Evavold, Iva Hafner-Bratkovič, Pascal Devant   +2 more
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Non-canonical mTORC1 signaling at the lysosome

Trends in Cell Biology, 2022
Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio   +2 more
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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Proceedings of the National Academy of Sciences of the United States of America, 2021
Kendall J Condon, JOSÉ M Orozco, Jessica B Spinelli   +2 more
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SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

Cell Metabolism, 2020
Shinji Kume, Sho Sugahara, Kosuke Yamahara   +2 more
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The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Nature Reviews Molecular Cell Biology, 2023
Roberta Peruzzo, Roberto Zoncu, Zoncu Roberto   +2 more
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mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

Cell, 2018
Stefan Pfeffer
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The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

Cell Metabolism, 2019
Fabin Dang, Zhengshuai Liu, Yu Li
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