Results 231 to 240 of about 63,525 (265)
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Science Signaling, 2013
A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
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A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
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Leucine and mTORC1: a complex relationship
American Journal of Physiology-Endocrinology and Metabolism, 2012Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When amino acid supplies become restricted, mammalian cells employ homeostatic mechanisms to rapidly inhibit processes such as protein synthesis, which demands high levels of amino acids.
Kayleigh M, Dodd, Andrew R, Tee
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TSC on the peroxisome controls mTORC1
Nature Cell Biology, 2013mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species.
Benjamin, D., Hall, M. N.
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mTORC1 signalling and mRNA translation
Biochemical Society Transactions, 2009Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
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Biochemical Society Transactions, 2011
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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Thwarting Dyskinesia by Targeting mTORC1
Science Signaling, 2009Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with l -DOPA treatment.
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Lysosomal cholesterol activates mTORC1
Science, 2017Cholesterol Sensing The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work has delineated a pathway through which amino acids regulate mTORC1.
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Cell, 2021Iva Hafner Bratković +2 more
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Non-canonical mTORC1 signaling at the lysosome
Trends in Cell Biology, 2022Chiara Di Malta +2 more
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
Cell, 2021Christiane Opitz +2 more
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