Results 231 to 240 of about 63,007 (266)
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Leucine and mTORC1: a complex relationship
American Journal of Physiology-Endocrinology and Metabolism, 2012Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When amino acid supplies become restricted, mammalian cells employ homeostatic mechanisms to rapidly inhibit processes such as protein synthesis, which demands high levels of amino acids.
Kayleigh M, Dodd, Andrew R, Tee
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Science Signaling, 2013
A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
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A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
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Biochemical Society Transactions, 2011
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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TSC on the peroxisome controls mTORC1
Nature Cell Biology, 2013mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species.
Benjamin, D., Hall, M. N.
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mTORC1 signalling and mRNA translation
Biochemical Society Transactions, 2009Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
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Science, 2016
Structural information reveals how a multiprotein complex responds to amino acid abundance [Also see Research Articles by Wolfson et al. and Aylett et al. and
Gwen R. Buel, John Blenis
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Structural information reveals how a multiprotein complex responds to amino acid abundance [Also see Research Articles by Wolfson et al. and Aylett et al. and
Gwen R. Buel, John Blenis
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Thwarting Dyskinesia by Targeting mTORC1
Science Signaling, 2009Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with l -DOPA treatment.
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