Results 211 to 220 of about 63,007 (266)

SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport. [PDF]

J Immunol
Tao AY, Hu K, Noyer L, Zhong L, Li W, Wang L, Feske S.   +6 more
europepmc   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Prominin-1 and Retinal Degenerative Disorders: Expanding the Biology from Photoreceptors to the Retinal Pigment Epithelium. [PDF]

Biomolecules
Bhattacharya S, Ang C, Soucy M, Tsang SH, Chaum E.   +4 more
europepmc   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review. [PDF]

Nutrients
Malaguarnera L, Sortino V, Surdo S, Piro S.   +3 more
europepmc   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB. [PDF]

Biochem J
Chu N, Le N, Nebie O, Yang S.
europepmc   +1 more source

Photobiomodulation Alleviates Insulin Resistance Induced by Intermittent Hypoxia, Through Preservation of Adipose Tissue Insulin Signaling and Reduction of Hepatic Oxidative Stress in Mice

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Photobiomodulation (PBM), through its organ‐specific action, exerts beneficial effects on metabolic complications induced by intermittent hypoxia (IH), making it a promising therapeutic strategy for preventing IH‐induced insulin resistance. Graphical abstract created from illustrations provided by BioRender.
Stéphanie Paradis, Britanny Blachot‐Minassian, Sophie Bouyon, Antoine Boutin, Amel Mohamadi, Guillaume Vial, Claire Arnaud, Elise Belaidi   +7 more
wiley   +1 more source

Defective autophagy in GNE myopathy is rescued by inhibition of noncanonical Akt-mTORC1 activation across multiple isogenic models. [PDF]

Exp Mol Med
Kim DW, Kwon EJ, Kwon H, Kim J, Cha HJ.
europepmc   +1 more source