Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao +9 more
wiley +1 more source
Proteostasis in the regulation of pancreatic islet cell plasticity
Journal of Diabetes Investigation, EarlyView.Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley +1 more source
mTOR signaling in cholangiocarcinoma: mechanistic insights and therapeutic opportunities. [PDF]
Front PharmacolChen Z, Peng T.
europepmc +1 more source
Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok +3 more
wiley +1 more source
Exploring the Neuroprotective Effects of Walnut (<i>Juglans regia</i> L.) Against Cognitive Impairment in Alzheimer's Disease Through the MAPK-mTORC1-TFEB-Mediated Endolysosomal Pathway: A Network Pharmacology and Molecular Docking Approach. [PDF]
Int J Mol SciLin CT, Chen KT, Hung YC.
europepmc +1 more source
Associations between diet quality and adult acne: A cross sectional study in the UK Biobank
Journal of the European Academy of Dermatology and Venereology, EarlyView.Mediterranean‐style diet adherence was associated with lower odds of adult acne, particularly in women. In men, a low‐carbohydrate, high‐meat dietary pattern showed higher odds. Cooked vegetables and yoghurt were inversely associated, whereas pork, skimmed milk and milk‐based desserts showed positive associations.
Bochen Li +7 more
wiley +1 more source
<i>Caenorhabditis</i> Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in <i>C. elegans</i>. [PDF]
MicroPubl BiolJohnson E +9 more
europepmc +1 more source
Modulation of sebocyte function in acne: A pathway‐inclusive review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis +3 more
wiley +1 more source
The cold-water immersion recovery-adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation. [PDF]
Exp PhysiolTornero-Aguilera JF +8 more
europepmc +1 more source
Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship
Journal of Periodontal Research, EarlyView.This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw +4 more
wiley +1 more source