Results 221 to 230 of about 63,525 (265)

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang, Shuwen Xue, Zhi Gao, Panlai Shi, Li Wang, Qi Feng, Xiangdong Kong, Xiaofan Zhu   +7 more
wiley   +1 more source

TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer. [PDF]

World J Oncol
Lee E, Al-Assi D, Rivera-Rueda R, Paul SS, Joy A.   +4 more
europepmc   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

Hyperactive muscle mTORC1 attenuates functional adaptations to endurance training despite alterations in mitochondrial and lipid profiles. [PDF]

J Appl Physiol (1985)
Kalenta H, Marchant ED, Kilroe SP, Maroto R, May JT, Bugay V, Romsdahl TB, Linares JJ, Hinojosa MR, Lai Z, Russell WK, Rasmussen BB.   +11 more
europepmc   +1 more source

Correction to "AMPK-Upregulated microRNA-708 Plays as a Suppressor of Cellular Senescence and Aging Via Downregulating Disabled-2 and mTORC1 Activation". [PDF]

MedComm (2020)
europepmc   +1 more source

SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport. [PDF]

J Immunol
Tao AY, Hu K, Noyer L, Zhong L, Li W, Wang L, Feske S.   +6 more
europepmc   +1 more source

Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review). [PDF]

Mol Med Rep
Nan S, Peng C, Meng X, Jia J, Zhao F, Cui Y.   +5 more
europepmc   +1 more source

Spatial biology of crowded tumor cells: A new map for designing drug combinations. [PDF]

Curr Opin Struct Biol
Nussinov R, Jang H.
europepmc   +1 more source

In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis. [PDF]

Orphanet J Rare Dis
Friedrich JE, Hentschel J, Richter S, Kiep H, Arélin M, Platzer K, Schulz T, Merkenschlager A, Kiess W, Mayer S, Jamra RA, Duc DL, Garten A, Kirstein AS.   +13 more
europepmc   +1 more source

Prominin-1 and Retinal Degenerative Disorders: Expanding the Biology from Photoreceptors to the Retinal Pigment Epithelium. [PDF]

Biomolecules
Bhattacharya S, Ang C, Soucy M, Tsang SH, Chaum E.   +4 more
europepmc   +1 more source