Results 221 to 230 of about 63,007 (266)

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

P62 in colorectal cancer: from inflammation suppression to cancer promotion. [PDF]

Front Immunol
A N, Huang J, Liu L, Chen H, Chen J, Zou S, Pang Y, Wu X, Liu M, Liang G.   +9 more
europepmc   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Mitochondrial impairment and mTORC1 signalling exhaustion define NK Cell dysfunction progression in melanoma. [PDF]

Cancer Immunol Immunother
Mylod E, Behan J, Baier D, Kelleher FC, Gardiner CM.   +4 more
europepmc   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

<i>BACE2</i> facilitates lung adenocarcinoma progression by enhancing mTORC1 signalling. [PDF]

Transl Cancer Res
You Z, He W, Zhou Y, Li H.
europepmc   +1 more source

Oncogenic SOX9-TRAIP signaling drives gastric cancer progression by mediating the degradation of the CPEB3-mTORC1 tumor suppressor axis. [PDF]

World J Surg Oncol
Zhou Y, Zhu J, Ouyang C, Liu W, Huang L, Zou L, Liu B, Lu Z.   +7 more
europepmc   +1 more source

Glutamine-Linked Cellular Stress Responses in Viral Infection: Mechanisms, Crosstalk, and Future Perspectives. [PDF]

Int J Mol Sci
Pham NTK, Trinh QD, Ushijima H, Komine-Aizawa S, Yoshimune K.   +4 more
europepmc   +1 more source

mTORC1 as a metabolic rheostat coordinates hormonal signals and cellular proliferation to sustain endometrial competence. [PDF]

Cell Mol Biol Lett
Sun Y, Wan S, Zhao M, Chen K, Wu Y, Huang Y, He J, Liu F, Shuai H, Yan J, Yang M.   +10 more
europepmc   +1 more source

Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer. [PDF]

Int J Biol Sci
Kayal Y, Farhoud M, Odeh M, Barash U, Naroditsky I, Bassal R, Nishioka Y, Sanderson RD, Ilan N, Vlodavsky I.   +9 more
europepmc   +1 more source